At the frontline of the host defence response, neutrophil antimicrobial functions have
adapted to combat infections and injuries of different origins and magnitude. The release of …

Neutrophils are critical to innate immunity, including host defense against bacterial and
fungal infections. They achieve their host defense role by phagocytosing pathogens …

Neutrophils are expanded and abundant in cancer-bearing hosts. Under the influence of
CXCR1 and CXCR2 chemokine receptor agonists and other chemotactic factors produced …

Neutrophil extracellular traps (NETs) evolved to protect the host against microbial infections
and are formed by a web-like structure of DNA that is decorated with antimicrobial effectors …

Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a
biologically uncontrolled process, whereas RCD involves tightly structured signaling …

The association between inflammation, infection, and venous thrombosis has long been
recognized; yet, only in the last decades have we begun to understand the mechanisms …

One of the most important mechanisms by which cancer fosters its own development is the
generation of an immune microenvironment that inhibits or impairs antitumor immune …

Acute lung injury (ALI) is a heterogeneous inflammatory condition associated with high
morbidity and mortality. Neutrophils play a key role in the development of different forms of …

Neutrophil extracellular traps (NETs) are web-like DNA structures decorated with histones
and cytotoxic proteins that are released by activated neutrophils to trap and neutralize …

Beyond their well-known functions in the acute phases of the immune response, neutrophils
play important roles in the various phases of tumor initiation and progression, through the …