Cutting through the noise: Noise-induced cochlear synaptopathy and individual differences in speech understanding among listeners with normal audiograms

M DiNino, LL Holt, BG Shinn-Cunningham - Ear and hearing, 2022 - journals.lww.com
Following a conversation in a crowded restaurant or at a lively party poses immense
perceptual challenges for some individuals with normal hearing thresholds. A number of …

Prevention of noise-induced hearing loss using investigational medicines for the inner ear: Previous trial outcomes should inform future trial design

CG Le Prell - Antioxidants & redox signaling, 2022 - liebertpub.com
Significance: Noise-induced hearing loss (NIHL) is an important public health issue resulting
in decreased quality of life for affected individuals, and significant costs to employers and …

Predicting synapse counts in living humans by combining computational models with auditory physiology

BN Buran, GP McMillan, S Keshishzadeh… - The Journal of the …, 2022 - pubs.aip.org
Aging, noise exposure, and ototoxic medications lead to cochlear synapse loss in animal
models. As cochlear function is highly conserved across mammalian species, synaptopathy …

[HTML][HTML] Modeling temporal information encoding by the population of fibers in the healthy and synaptopathic auditory nerve

PT Johannesen, T Leclère, A Wijetillake… - Hearing Research, 2022 - Elsevier
We report a theoretical study aimed at investigating the impact of cochlear synapse loss
(synaptopathy) on the encoding of the envelope (ENV) and temporal fine structure (TFS) of …

The effect of lifetime noise exposure and aging on speech-perception-in-noise ability and self-reported hearing symptoms: An online study

AM Shehabi, G Prendergast, H Guest… - Frontiers in aging …, 2022 - frontiersin.org
Animal research shows that aging and excessive noise exposure damage cochlear outer
hair cells, inner hair cells, and the synapses connecting inner hair cells with the auditory …

[HTML][HTML] Temporal acuity is preserved in the auditory midbrain of aged mice

R Land, A Kral - Neurobiology of aging, 2022 - Elsevier
Impaired temporal resolution of the central auditory system has long been suggested to
contribute to speech understanding deficits in the elderly. However, it has been difficult to …

Cochlear synaptopathy and hidden hearing loss: a scoping review

MF Colla, PP Lunardelo, FAM Dias - Codas, 2023 - SciELO Brasil
Purpose: To identify the pathophysiological definitions adopted by studies investigating
“cochlear synaptopathy”(CS) and “hidden hearing loss”(HHL). Research strategies: The …

Music Perception in Older Adults With Hearing Loss: Protective Effect of Musical Experience

A Whittom, L Chauvette, A Bégin, I Blanchette… - Ear and …, 2024 - journals.lww.com
Objectives: The goal of this project was to investigate the impact of musical experience,
hearing loss, and age on music perception in older adults. The authors hypothesized that …

The relative and combined effects of noise exposure and aging on auditory peripheral neural deafferentation: A narrative review

AM Shehabi, G Prendergast, CJ Plack - Frontiers in aging …, 2022 - frontiersin.org
Animal studies have shown that noise exposure and aging cause a reduction in the number
of synapses between low and medium spontaneous rate auditory nerve fibers and inner hair …

BPACE: A Bayesian, Patient-Centered Procedure for Matrix Speech Tests in Noise

C Schmid, W Wimmer, M Kompis - Trends in hearing, 2023 - journals.sagepub.com
Matrix sentence tests in noise can be challenging to the listener and time-consuming. A
trade-off should be found between testing time, listener's comfort and the precision of the …