Inflammation-induced DNA damage, mutations and cancer
The relationships between inflammation and cancer are varied and complex. An important
connection linking inflammation to cancer development is DNA damage. During …
connection linking inflammation to cancer development is DNA damage. During …
Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling
The complexity of human DNA has been affected by aerobic metabolism, including
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …
Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: role of microbiome
D Abraham, J Feher, GL Scuderi, D Szabo… - Experimental …, 2019 - Elsevier
It has been suggested that exercise training and probiotic supplementation could decelerate
the progress of functional and biochemical deterioration in APP/PS1 transgenic mice …
the progress of functional and biochemical deterioration in APP/PS1 transgenic mice …
Base excision repair: a critical player in many games
SS Wallace - DNA repair, 2014 - Elsevier
This perspective reviews the many dimensions of base excision repair from a 10,000 foot
vantage point and provides one person's view on where the field is headed. Enzyme …
vantage point and provides one person's view on where the field is headed. Enzyme …
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
The onset of inflammation is associated with reactive oxygen species and oxidative damage
to macromolecules like 7, 8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine …
to macromolecules like 7, 8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine …
Traumatic brain injury: oxidative stress and neuroprotection
C Cornelius, R Crupi, V Calabrese… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: A vast amount of circumstantial evidence implicates high energy oxidants and
oxidative stress as mediators of secondary damage associated with traumatic brain injury …
oxidative stress as mediators of secondary damage associated with traumatic brain injury …
[HTML][HTML] Not breathing is not an option: How to deal with oxidative DNA damage
E Markkanen - DNA repair, 2017 - Elsevier
Oxidative DNA damage constitutes a major threat to genetic integrity, and has thus been
implicated in the pathogenesis of a wide variety of diseases, including cancer and …
implicated in the pathogenesis of a wide variety of diseases, including cancer and …
[HTML][HTML] Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve
Z Radak, K Ishihara, E Tekus, C Varga, A Posa… - Redox biology, 2017 - Elsevier
It is debated whether exercise-induced ROS production is obligatory to cause adaptive
response. It is also claimed that antioxidant treatment could eliminate the adaptive response …
response. It is also claimed that antioxidant treatment could eliminate the adaptive response …
Oxidized guanine base lesions function in 8-oxoguanine DNA glycosylase-1-mediated epigenetic regulation of nuclear factor κB-driven gene expression
L Pan, B Zhu, W Hao, X Zeng, SA Vlahopoulos… - Journal of Biological …, 2016 - ASBMB
A large percentage of redox-responsive gene promoters contain evolutionarily conserved
guanine-rich clusters; guanines are the bases most susceptible to oxidative modification (s) …
guanine-rich clusters; guanines are the bases most susceptible to oxidative modification (s) …
Oxidative stress damage-associated molecular signaling pathways differentiate spontaneous preterm birth and preterm premature rupture of the membranes
EH Dutta, F Behnia, I Boldogh… - MHR: Basic science …, 2016 - academic.oup.com
STUDY HYPOTHESIS In women with preterm premature rupture of the membranes
(PPROM), increased oxidative stress may accelerate premature cellular senescence …
(PPROM), increased oxidative stress may accelerate premature cellular senescence …