[HTML][HTML] Mechanisms of noise-induced tinnitus: insights from cellular studies

SE Shore, C Wu - Neuron, 2019 - cell.com
Tinnitus, sound perception in the absence of physical stimuli, occurs in 15% of the
population and is the top-reported disability for soldiers after combat. Noise overexposure is …

Vulnerability to chronic stress and the phenotypic heterogeneity of presbycusis with subjective tinnitus

J Ruan, X Hu, Y Liu, Z Han, Q Ruan - Frontiers in Neuroscience, 2022 - frontiersin.org
Age-related functional reserve decline and vulnerability of multiple physiological systems
and organs, as well as at the cellular and molecular levels, result in different frailty …

Lower glutamate and GABA levels in auditory cortex of tinnitus patients: a 2D-JPRESS MR spectroscopy study

B Isler, N Von Burg, T Kleinjung, M Meyer, P Stämpfli… - Scientific Reports, 2022 - nature.com
We performed magnetic resonance spectroscopy (MRS) on healthy individuals with tinnitus
and no hearing loss (n= 16) vs. a matched control group (n= 17) to further elucidate the role …

Reversing synchronized brain circuits using targeted auditory-somatosensory stimulation to treat phantom percepts: a randomized clinical trial

GR Jones, DT Martel, TL Riffle, J Errickson… - JAMA Network …, 2023 - jamanetwork.com
Importance Animal models have shown altered dorsal cochlear nucleus circuitry in animals
that develop tinnitus; however, precise treatment using bisensory (auditory and …

Blast-induced central auditory neurodegeneration affects tinnitus development regardless of peripheral cochlear damage

T Kurioka, K Mizutari, Y Satoh, Y Kobayashi… - Journal of …, 2024 - liebertpub.com
Blast exposure causes serious complications, the most common of which are ear-related
symptoms such as hearing loss and tinnitus. The blast shock waves can cause …

Decreasing dorsal cochlear nucleus activity ameliorates noise-induced tinnitus perception in mice

T Malfatti, B Ciralli, MM Hilscher, RN Leao, KE Leao - BMC biology, 2022 - Springer
Background The dorsal cochlear nucleus (DCN) is a region known to integrate
somatosensory and auditory inputs and is identified as a potential key structure in the …

Restoration of deafferentation reduces tinnitus, anxiety, and depression: a retrospective study on cochlear implant patients

J Yang, J Song, X Zhao, C Pang, N Cong… - Neural …, 2021 - Wiley Online Library
Patients with profound bilateral deafness (BD) are prone to suffering from tinnitus, which
further leads to psychological comorbidities and makes it more difficult for patients to …

Tinnitus development is associated with synaptopathy of inner hair cells in Mongolian gerbils

K Tziridis, J Forster, I Buchheidt‐Dörfler… - European Journal of …, 2021 - Wiley Online Library
Human hearing loss (HL) is often accompanied by comorbidities like tinnitus, which is
affecting up to 15% of the adult population. Rodent animal studies could show that tinnitus …

Overview: Hearing loss, tinnitus, hyperacusis, and the role of central gain

LE Roberts, R Salvi - Neuroscience, 2019 - Elsevier
Sensory hair cells in the cochlea transduce environmental sounds into driven high-fidelity
neural signals that are conveyed by auditory nerve fibers to structures in the central auditory …

Noise exposure alters glutamatergic and GABAergic synaptic connectivity in the hippocampus and its relevance to tinnitus

L Zhang, C Wu, DT Martel, M West, MA Sutton… - Neural …, 2021 - Wiley Online Library
Accumulating evidence implicates a role for brain structures outside the ascending auditory
pathway in tinnitus, the phantom perception of sound. In addition to other factors such as …