Genetic regulation and manipulation of nicotine biosynthesis in tobacco: strategies to eliminate addictive alkaloids
T Shoji, T Hashimoto, K Saito - Journal of Experimental Botany, 2024 - academic.oup.com
Tobacco (Nicotiana tabacum L.) is a widely cultivated crop of the genus Nicotiana. Due to
the highly addictive nature of tobacco products, tobacco smoking remains the leading cause …
the highly addictive nature of tobacco products, tobacco smoking remains the leading cause …
A reference genome for Nicotiana tabacum enables map-based cloning of homeologous loci implicated in nitrogen utilization efficiency
Abstract Background Tobacco (Nicotiana tabacum) is an important plant model system that
has played a key role in the early development of molecular plant biology. The tobacco …
has played a key role in the early development of molecular plant biology. The tobacco …
From cultivation to cancer: formation of N-nitrosamines and other carcinogens in smokeless tobacco and their mutagenic implications
SB Stanfill, SS Hecht, AC Joerger… - Critical Reviews in …, 2023 - Taylor & Francis
Tobacco use is a major cause of preventable morbidity and mortality globally. Tobacco
products, including smokeless tobacco (ST), generally contain tobacco-specific N …
products, including smokeless tobacco (ST), generally contain tobacco-specific N …
Physiological, transcriptome and co-expression network analysis of chlorophyll-deficient mutants in flue-cured tobacco
Y Feng, Y Li, Y Zhao, H Shi - BMC Plant Biology, 2023 - Springer
Background Photosynthetic pigments in higher plants, including chlorophyll (Chl) and
carotenoids, are crucial for photosynthesis and photoprotection. Chl-deficient tobacco …
carotenoids, are crucial for photosynthesis and photoprotection. Chl-deficient tobacco …
Nitrate and nitrite promote formation of tobacco‐specific nitrosamines via nitrogen oxides intermediates during postcured storage under warm temperature
J Wang, H Yang, H Shi, J Zhou, R Bai… - Journal of …, 2017 - Wiley Online Library
Tobacco‐specific nitrosamines (TSNAs) are carcinogenic and are present in cured tobacco
leaves. This study was designed to elucidate the mechanisms of TSNAs formation under …
leaves. This study was designed to elucidate the mechanisms of TSNAs formation under …
Impairing both HMA4 homeologs is required for cadmium reduction in tobacco
V Liedschulte, H Laparra, JND Battey… - Plant, Cell & …, 2017 - Wiley Online Library
In tobacco, the heavy metal P1B‐ATPases HMA4. 1 and HMA4. 2 function in root‐to‐shoot
zinc and cadmium transport. We present greenhouse and field data that dissect the …
zinc and cadmium transport. We present greenhouse and field data that dissect the …
Decreased Tobacco-Specific Nitrosamines by Microbial Treatment with Bacillus amyloliquefaciens DA9 during the Air-Curing Process of Burley Tobacco
X Wei, X Deng, D Cai, Z Ji, C Wang, J Yu… - Journal of agricultural …, 2014 - ACS Publications
Tobacco specific nitrosamines (TSNA) mainly consisting of N-nitrosonornicotine (NNN), N-
nitrosoanatabine (NAT), N-nitrosoanabasine (NAB), and 4-(methylnitrosamino)-1-(3-pyridyl) …
nitrosoanatabine (NAT), N-nitrosoanabasine (NAB), and 4-(methylnitrosamino)-1-(3-pyridyl) …
Expression of a constitutively active nitrate reductase variant in tobacco reduces tobacco‐specific nitrosamine accumulation in cured leaves and cigarette smoke
J Lu, L Zhang, RS Lewis, L Bovet… - Plant biotechnology …, 2016 - Wiley Online Library
Burley tobaccos (Nicotiana tabacum) display a nitrogen‐use‐deficiency phenotype that is
associated with the accumulation of high levels of nitrate within the leaf, a trait correlated …
associated with the accumulation of high levels of nitrate within the leaf, a trait correlated …
Effects of tobacco nitrate content on free radical levels in mainstream smoke
LE Mocniak, ZT Bitzer, N Trushin, JP Richie - Free Radical Biology and …, 2022 - Elsevier
Tobacco smoke free radicals play an important role in the development of smoking related
adverse health effects. We previously reported that gas phase (GP) radicals vary greatly by …
adverse health effects. We previously reported that gas phase (GP) radicals vary greatly by …
An update on the formation in tobacco, toxicity and carcinogenicity of Nʹ-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
LA Peterson, SB Stanfill, SS Hecht - Carcinogenesis, 2024 - academic.oup.com
The tobacco-specific nitrosamines N ʹ-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-
1-(3-pyridyl)-1-butanone (NNK) are considered 'carcinogenic to humans' by the International …
1-(3-pyridyl)-1-butanone (NNK) are considered 'carcinogenic to humans' by the International …