The cell biology of synapse formation

TC Südhof - Journal of Cell Biology, 2021 - rupress.org
In a neural circuit, synapses transfer information rapidly between neurons and transform this
information during transfer. The diverse computational properties of synapses are shaped by …

[HTML][HTML] The impact of maternal immune activation on GABAergic interneuron development: A systematic review of rodent studies and their translational implications

B Gillespie, S Panthi, S Sundram, RA Hill - Neuroscience & Biobehavioral …, 2024 - Elsevier
Mothers exposed to infections during pregnancy disproportionally birth children who
develop autism and schizophrenia, disorders associated with altered GABAergic function …

GABAergic restriction of network dynamics regulates interneuron survival in the developing cortex

ZRS Duan, A Che, P Chu, L Modol, Y Bollmann… - Neuron, 2020 - cell.com
During neonatal development, sensory cortices generate spontaneous activity patterns
shaped by both sensory experience and intrinsic influences. How these patterns contribute …

A novel spinal neuron connection for heat sensation

H Wang, W Chen, Z Dong, G Xing, W Cui, L Yao… - Neuron, 2022 - cell.com
Heat perception enables acute avoidance responses to prevent tissue damage and
maintain body thermal homeostasis. Unlike other modalities, how heat signals are …

Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects

J Scekic-Zahirovic, I Sanjuan-Ruiz, V Kan… - Nature …, 2021 - nature.com
Gene mutations causing cytoplasmic mislocalization of the RNA-binding protein FUS lead to
severe forms of amyotrophic lateral sclerosis (ALS). Cytoplasmic accumulation of FUS is …

The γ-protocadherins regulate the survival of GABAergic interneurons during developmental cell death

CH Carriere, WX Wang, AD Sing, A Fekete… - Journal of …, 2020 - Soc Neuroscience
Inhibitory interneurons integrate into developing circuits in specific ratios and distributions. In
the neocortex, inhibitory network formation occurs concurrently with the apoptotic elimination …

Genetic recovery of ErbB4 in adulthood partially restores brain functions in null mice

H Wang, F Liu, W Chen, X Sun, W Cui… - Proceedings of the …, 2018 - National Acad Sciences
Neurotrophic factor NRG1 and its receptor ErbB4 play a role in GABAergic circuit assembly
during development. ErbB4 null mice possess fewer interneurons, have decreased GABA …

ErbB4 promotes inhibitory synapse formation by cell adhesion, independent of its kinase activity

B Luo, Z Liu, D Lin, W Chen, D Ren, Z Yu… - Translational …, 2021 - nature.com
The precise control of the nervous system function under the vitality of synapses is extremely
critical. Efforts have been taken to explore the underlying cellular and molecular …

Identifying genes that affect differentiation of human neural stem cells and myelination of mature oligodendrocytes

D Ye, Q Wang, Y Yang, B Chen, F Zhang… - Cellular and Molecular …, 2023 - Springer
Human neural stem cells (NSCs) are self-renewing, multipotent cells of the central nervous
system (CNS). They are characterized by their ability to differentiate into a range of cells …

LncRNA EGOT/miR-211-5p affected radiosensitivity of rectal cancer by competitively regulating ErbB4

C Li, H Liu, R Wei, Z Liu, H Chen, X Guan… - OncoTargets and …, 2021 - Taylor & Francis
Background/Aims Long non-coding ribonucleic acids (lncRNAs) are involved in the
progression of cancers and affect the response to radiation therapy. This study was to …