Macrophages in health and disease

MD Park, A Silvin, F Ginhoux, M Merad - Cell, 2022 - cell.com
The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

Immune cell-mediated features of non-alcoholic steatohepatitis

T Huby, EL Gautier - Nature reviews immunology, 2022 - nature.com
Non-alcoholic fatty liver disease (NAFLD) includes a range of hepatic manifestations,
starting with liver steatosis and potentially evolving towards non-alcoholic steatohepatitis …

Mechanisms and disease consequences of nonalcoholic fatty liver disease

R Loomba, SL Friedman, GI Shulman - Cell, 2021 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

S Xu, O Chaudhary, P Rodríguez-Morales, X Sun… - Immunity, 2021 - cell.com
A common metabolic alteration in the tumor microenvironment (TME) is lipid accumulation, a
feature associated with immune dysfunction. Here, we examined how CD8+ tumor infiltrating …

Innate immune detection of lipid oxidation as a threat assessment strategy

D Zhivaki, JC Kagan - Nature Reviews Immunology, 2022 - nature.com
Oxidized phospholipids that result from tissue injury operate as immunomodulatory signals
that, depending on the context, lead to proinflammatory or anti-inflammatory responses. In …

Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia

Y Dong, C D'Mello, W Pinsky, BM Lozinski… - Nature …, 2021 - nature.com
Neurodegeneration occurring in multiple sclerosis (MS) contributes to the progression of
disability. It is therefore important to identify and neutralize the mechanisms that promote …

[HTML][HTML] Metabolic drivers of non-alcoholic fatty liver disease

KK Bence, MJ Birnbaum - Molecular metabolism, 2021 - Elsevier
Background The incidence of non-alcoholic fatty liver disease (NAFLD) is rapidly increasing
worldwide parallel to the global obesity epidemic. NAFLD encompasses a range of liver …

Lipids as regulators of cellular senescence

S Hamsanathan, AU Gurkar - Frontiers in physiology, 2022 - frontiersin.org
Lipids are key macromolecules that perform a multitude of biological functions ranging from
maintaining structural integrity of membranes, energy storage, to signaling molecules …

Oxidative stress in NAFLD: role of nutrients and food contaminants

C Rives, A Fougerat, S Ellero-Simatos, N Loiseau… - Biomolecules, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is often the hepatic expression of metabolic
syndrome and its comorbidities that comprise, among others, obesity and insulin-resistance …

Nuclear receptors linking metabolism, inflammation, and fibrosis in nonalcoholic fatty liver disease

T Puengel, H Liu, A Guillot, F Heymann… - International journal of …, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) and its progressive form nonalcoholic
steatohepatitis (NASH) comprise a spectrum of chronic liver diseases in the global …