Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality
control to maintain homeostasis under different conditions and disease states characterized …

Autophagy, an intracellular conserved degradative process, plays a central role in the
renewal/recycling of a cell to maintain the homeostasis of nutrients and energy within the …

The precise mechanism through which macroautophagy/autophagy affects psoriasis is
poorly understood. Here, we found that keratinocyte (KC) autophagy, which was positively …

Psoriasis is an immune-mediated inflammatory disease of the skin. Previous studies
including ours have shown that IL-17A plays a major role in its pathogenesis; however, its …

Autophagy is a highly conserved lysosomal degradation system that involves the creation of
autophagosomes, which eventually fuse with lysosomes and breakdown misfolded proteins …

The epidermis regenerates continually to maintain a protective barrier at the body's surface
composed of differentiating keratinocytes. Maturation of this stratified tissue requires that …

Trehalose is a natural disaccharide that is found in a diverse range of organisms but not in
mammals. Autophagy is a process which mediates the sequestration, lysosomal delivery …

Background Psoriasis is an immune-mediated chronic inflammatory skin disease
characterized by well-defined erythema and white scales, which affects approximately 2% of …

At a time when complex diseases affect globally 280 million people and claim 14 million
lives every year, there is an urgent need to rapidly increase our knowledge into their …

Atopic dermatitis and psoriasis are frequent chronic inflammatory skin diseases. Autophagy
plays a substantial role in the homeostasis of an organism. Loss or impairment of autophagy …