In the mid 1960s, experimental work on molecules under screening as coronary dilators
allowed the discovery of the mechanism of calcium entry blockade by drugs later named …

Aggregation and deposition of β-amyloid and/or tau protein are the key neuropathological
features in neurodegenerative disorders such as Alzheimer's disease (AD) and other …

Preeclampsia is the most frequent pregnancy-related complication worldwide with no cure.
While a number of molecular features have emerged, the underlying causal mechanisms …

Abstract Purpose of Review To review the pathophysiology of hypertension in Alzheimer's
disease and related dementias and explore the current landscape of clinical trials involving …

Calcium channel blockers (CCBs) are an established class of drug for the management of
hypertension. Observational studies have found that CCB use is associated with a reduction …

Almost 115 years ago, Alois Alzheimer described Alzheimer's disease (AD) for the first time.
Since then, many hypotheses have been proposed. However, AD remains a severe health …

Study Design. The effect of amlodipine (AM) on spinal cord injury (SCI) and autophagy was
researched by establishing ventral spinal cord cells (VSC4. 1) oxygen and glucose …

This study investigates the effect of epigallocatechin-3-gallate (EGCG), a major ingredient of
green tea, on the pharmacokinetics of amlodipine in rats. The pharmacokinetics of orally …

Background The effect of calcium channel blockers (CCB) on mortality and ischaemic stroke
risk in dementia patients is understudied. Objectives To calculate the risk of death and …

Dementia is a clinical syndrome characterized by progressive impairment of cognitive and
functional abilities. As currently applied treatments for dementia can only delay the …