KATP Channels in the Cardiovascular System

MN Foster, WA Coetzee - Physiological reviews, 2016 - journals.physiology.org
KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

KATP channels are regulators of programmed cell death and targets for the creation of novel drugs against ischemia/reperfusion cardiac injury

LN Maslov, SV Popov, NV Naryzhnaya… - Fundamental & …, 2023 - Wiley Online Library
Background The use of percutaneous coronary intervention (PCI) in patients with ST‐
segment elevation myocardial infarction (STEMI) is associated with a mortality rate of 5 …

Persistent beneficial effect of postconditioning against infarct size: role of mitochondrial KATP channels during reperfusion

J Mykytenko, JG Reeves, H Kin, NP Wang… - Basic research in …, 2008 - Springer
This study tested the hypothesis that inhibition of myocardial injury and modulation of
mitochondrial dysfunction by postconditioning (Postcon) after 24 h of reperfusion is …

The cardiac sarcolemmal ATP-sensitive potassium channel as a novel target for anti-arrhythmic therapy

GE Billman - Pharmacology & therapeutics, 2008 - Elsevier
The activation of cardiac cell membrane ATP-sensitive potassium channels during
myocardial ischemia promotes potassium efflux, reductions in action potential duration, and …

Sex-specific and exercise-acquired cardioprotection is abolished by sarcolemmal KATP channel blockade in the rat heart

AJ Chicco, MS Johnson… - American Journal …, 2007 - journals.physiology.org
The present study was conducted to determine whether the infarct sparing effect of short-
term exercise is dependent on the operation of the myocardial sarcolemmal ATP-sensitive …

Selective cardiac plasma-membrane KATP channel inhibition is defibrillatory and improves survival during acute myocardial ischemia and reperfusion

S Vajda, I Baczkó, I Leprán - European journal of pharmacology, 2007 - Elsevier
ATP-dependent potassium channels (KATP) have been implicated in cardioprotection both
during myocardial ischemia and reperfusion. We compared the effect of a non-selective …

Role of reactive oxygen species in the regulation of cardiac contractility

AM Kubin, R Skoumal, P Tavi, A Kónyi, Á Perjés… - Journal of Molecular and …, 2011 - Elsevier
Increased production of reactive oxygen species (ROS) has been linked to the pathogenesis
of contractile dysfunction in heart failure. However, it is unclear whether ROS can regulate …

Sarcolemmal KATP channel modulators and cardiac arrhythmias

I Baczkó, Z Husti, V Lang, I Leprán… - Current medicinal …, 2011 - ingentaconnect.com
Cardiac atrial and ventricular arrhythmias are major causes of mortality and morbidity.
Ischemic heart disease is the most common cause underlying 1) the development of …

Both mitochondrial KATP channel opening and sarcolemmal KATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in …

E Gonca, Ö Bozdoğan - Journal of cardiovascular …, 2010 - journals.sagepub.com
Aim: This study was performed to assess the effect of selective sarcolemmal adenosine
triphosphate (ATP)-sensitive K+ channel (KATP) inhibition and the mitochondrial KATP …

ATP-sensitive potassium channel modulators and cardiac arrhythmias: an update

DM Muntean, L Kiss, N Jost… - Current Pharmaceutical …, 2015 - ingentaconnect.com
Ischemia and heart failure-related cardiac arrhythmias, both atrial (eg, atrial fibrillation) and
ventricular (eg, malignant tachyarrhythmias) represent a leading cause of morbidity and …