The causative agent of human tuberculosis, Mycobacterium tuberculosis complex (MTBC),
comprises seven phylogenetically distinct lineages associated with different geographical …

Tuberculosis (TB) remains the second most common cause of death due to a single
infectious agent. The cell envelope of Mycobacterium tuberculosis (Mtb), the causative agent …

Pulmonary tuberculosis, a disease caused by Mycobacterium tuberculosis (Mtb), manifests
with a persistent cough as both a primary symptom and mechanism of transmission. The …

Although the bovine tuberculosis (TB) agent, Mycobacterium bovis, may infect humans and
cause disease, long-term epidemiological data indicate that humans represent a spill-over …

The publication of the complete genome sequence for Mycobacterium tuberculosis H37Rv
in 1998 has had a great impact on the research community. Nonetheless, it is suspected that …

Analysis of mycobacterial strains that have lost their ability to cause disease is a powerful
approach to identify yet unknown virulence determinants and pathways involved in …

Inactivation of the transcriptional regulator PhoP results in Mycobacterium tuberculosis
attenuation. Preclinical testing has shown that attenuated M. tuberculosis phoP mutants hold …

Tuberculosis, caused by Mycobacterium tuberculosis, remains a leading infectious disease
despite the availability of chemotherapy and BCG vaccine. The commonly used avirulent M …

At its 100th birthday of its first administration to a newborn, BCG has been (and continues
being) an inspiration for the construction and development of hundreds of new TB vaccine …

Mycobacterium bovis Bacille Calmette-Guérin (BCG) was developed as an attenuated live
vaccine for tuberculosis control nearly a century ago. Despite being the most widely used …