Importance Previous studies on the comparative effectiveness between buprenorphine and
methadone provided limited evidence on differences in treatment effects across key …

Buprenorphine is an effective treatment for opioid use disorder but can be slow when using
a standard low-dose titration protocol to avoid precipitated withdrawal. This presents a …

Buprenorphine has superior safety in opioid use disorder compared with alternatives due to
its action as a partial opioid agonist, which limits its ability to cause respiratory depression …