A review on evaluation of technetium-99m labeled radiopharmaceuticals

MU Akbar, MR Ahmad, A Shaheen… - Journal of Radioanalytical …, 2016 - Springer
In the past few years, substantial progress has been made in technetium chemistry,
including the synthesis of a variety of 99m Tc-radiopharmaceuticals. This synthesis can be …

Discovery and design of radiopharmaceuticals by in silico methods

M Salahinejad, DA Winkler… - Current …, 2022 - ingentaconnect.com
There has been impressive growth in the use of radiopharmaceuticals for therapy, selective
toxic payload delivery, and noninvasive diagnostic imaging of disease. The increasing …

99mTc-linezolid as a radiotracer for brain abscess: labeling, in silico docking, and biodistribution studies

OA El-Kawy, IT Ibrahim, HA Shweeta… - Applied Radiation and …, 2023 - Elsevier
Brain abscess is a life-threatening condition that requires a timely and accurate diagnosis. In
this study, linezolid, an oxazolidinone antibiotic, was labeled with technetium-99m according …

Radioiodination, nasal nanoformulation and preliminary evaluation of isovanillin: a new potential brain cancer-targeting agent

OA El-Kawy, HA Shweeta, KM Attallah - Applied Radiation and Isotopes, 2022 - Elsevier
Brain cancer is a challenging disease to treat using conventional approaches. The present
investigation aimed to develop a radiopharmaceutical targeting brain cancer based on …

Preparation and evaluation of radiolabeled gliclazide parenteral nanoemulsion as a new tracer for pancreatic β-cells mass

OA El-Kawy, IT Ibrahim, HA Shewatah… - International Journal of …, 2023 - Taylor & Francis
Purpose The present investigation aims to develop and evaluate a radiopharmaceutical for
targeting and assessing β-cells mass based on gliclazide, an antidiabetic drug that …

Preparation and preliminary evaluation study of [131I]iodocolchicine-gallic-AuNPs: a potential scintigraphic agent for inflammation detection

BM Essa, AA Selim, OA El-Kawy… - International journal of …, 2022 - Taylor & Francis
Background Nanomedicine offers great potential for scintigraphic diagnostic imaging with
lower risk and higher quality compared to other traditional techniques. Objectives This work …

Radiolabeling, characterization, and preclinical evaluation of plazomicin: A potential tracer for bacterial infection

OA El‐kawy, G Abdelaziz… - Chemical Biology & …, 2022 - Wiley Online Library
In this study, 99mTc–plazomicin, a new radio‐antibiotic complex, was prepared specifically
for bacterial infection localization and monitoring. Factors affecting the labeling reaction …

Preparation and evaluation of 99mTc-anidulafungin: a potential radiotracer for fungal infection

OA El-Kawy, MS Sayed, AS Abdel-Razek - Journal of Radioanalytical and …, 2020 - Springer
Aiming to develop specific diagnostic tool for invasive fungal infection, a
radiopharmaceutical based on anidulafungin was investigated. A two-step approach was …

Labelling, molecular modelling and biological evaluation of vardenafil: a potential agent for diagnostic evaluation of erectile dysfunction

OA El-Kawy, JA García-Horsman… - Applied Radiation and …, 2016 - Elsevier
Abstract 99m Tc–tricarbonyl–vardenafil was specifically radiosynthesized for diagnostic
evaluation of erectile dysfunction with a radiochemical yield~ 97.2%. It was stable in saline …

Preparation and evaluation of radiolabeled acetaminosalol microspheres: A new potential selective radiotracer for ulcerative colitis early diagnosis

OA El‐Kawy, HA Shweeta… - Journal of Labelled …, 2024 - Wiley Online Library
Acetaminosalol labeling reaction with technetium‐99m was optimized, and the
radiocomplex was obtained in a high radiochemical yield of 98.9±0.6% and high stability (> …