Acute kidney injury (AKI) due to renal ischemia reperfusion (IR) is a major clinical problem
without effective therapy and is a significant and frequent cause of morbidity and mortality …

Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the
world. There is growing evidence that they could also be promising therapeutic targets in a …

Adenosine is involved in a range of physiological and pathological effects through
membrane-bound receptors linked to G proteins. There are four subtypes of adenosine …

In this review we outline the unique effects of the autacoid adenosine in the kidney.
Adenosine is present in the cytosol of renal cells and in the extracellular space of normoxic …

Current strategies to limit the extent of injury in acute renal failure are based on extensive
studies that identified cellular and molecular mechanisms of acute kidney injury. Despite …

Adenosine is a potent endogenous regulator of inflammation and tissue repair. Adenosine,
which is released from injured and hypoxic tissue or in response to toxins and medications …

Adenosine is a primordial signaling molecule present in every cell of the human body that
mediates its physiological functions by interacting with 4 subtypes of G-protein-coupled …

Abstract The A 1, A 2A, A 2B and A 3 G-protein-coupled cell surface adenosine receptors
(ARs) are found to be upregulated in various tumor cells. Activation of the receptors by …

Ischemia/reperfusion-induced acute renal failure is a common clinical problem associated
with a high morbidity and mortality. Upon hypoxic injury, the depletion of ATP causes …

The involvement of purinergic signalling in kidney physiology and pathophysiology is rapidly
gaining recognition and this is a comprehensive review of early and recent publications in …