Proteolytic removal of membrane protein ectodomains (ectodomain shedding) is a post‐
translational modification that controls levels and function of hundreds of membrane …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Genetic variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been
linked to Nasu-Hakola disease, Alzheimer's disease (AD), Parkinson's disease, amyotrophic …

The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane
and secreted proteins with important roles in regulating cell phenotype via their effects on …

Abstract Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM)
and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc …

Cytokines receptors exist in membrane bound and soluble form. A soluble form of the
human IL-6R is generated by limited proteolysis and alternative splicing. The complex of IL …

Heterozygous germ-line mutations in the bone morphogenetic protein type-II receptor
(BMPR-II) gene underlie heritable pulmonary arterial hypertension (HPAH). Although …

S taphylococcus aureus is a major cause of human disease, responsible for half a million
infections and approximately 20,000 deaths per year in the United States alone,. This …

Proteases enzymatically hydrolyze peptide bonds in substrate proteins, resulting in a
widespread, irreversible posttranslational modification of the protein's structure and …

A disintegrin and metalloproteinases (ADAMs) are a new gene family of proteins with
sequence similarity to the reprolysin family of snake venomases that share the …