From femtoseconds to hours—measuring dynamics over 18 orders of magnitude with coherent x-rays

F Lehmkühler, W Roseker, G Grübel - Applied Sciences, 2021 - mdpi.com
X-ray photon correlation spectroscopy (XPCS) enables the study of sample dynamics
between micrometer and atomic length scales. As a coherent scattering technique, it …

Current understanding of molecular phase separation in chromosomes

JK Ryu, DE Hwang, JM Choi - International Journal of Molecular Sciences, 2021 - mdpi.com
Biomolecular phase separation denotes the demixing of a specific set of intracellular
components without membrane encapsulation. Recent studies have found that biomolecular …

Exploring non-equilibrium processes and spatio-temporal scaling laws in heated egg yolk using coherent X-rays

ND Anthuparambil, A Girelli, S Timmermann… - Nature …, 2023 - nature.com
The soft-grainy microstructure of cooked egg yolk is the result of a series of out-of-
equilibrium processes of its protein-lipid contents; however, it is unclear how egg yolk …

Resolving molecular diffusion and aggregation of antibody proteins with megahertz X-ray free-electron laser pulses

M Reiser, A Girelli, A Ragulskaya, S Das… - Nature …, 2022 - nature.com
X-ray free-electron lasers (XFELs) with megahertz repetition rate can provide novel insights
into structural dynamics of biological macromolecule solutions. However, very high dose …

Probing cage relaxation in concentrated protein solutions by X-ray photon correlation spectroscopy

Y Chushkin, A Gulotta, F Roosen-Runge, A Pal… - Physical Review Letters, 2022 - APS
Diffusion of proteins on length scales of their size is crucial for understanding the machinery
of living cells. X-ray photon correlation spectroscopy (XPCS) is currently the only way to …

AI-NERD: Elucidation of relaxation dynamics beyond equilibrium through AI-informed X-ray photon correlation spectroscopy

JP Horwath, XM Lin, H He, Q Zhang… - Nature …, 2024 - nature.com
Understanding and interpreting dynamics of functional materials in situ is a grand challenge
in physics and materials science due to the difficulty of experimentally probing materials at …

Phase transition dynamics in a complex oxide heterostructure

Q Zhang, G Hu, V Starchenko, G Wan, EM Dufresne… - Physical Review Letters, 2022 - APS
Understanding the behavior of defects in the complex oxides is key to controlling myriad
ionic and electronic properties in these multifunctional materials. The observation of defect …

Soft matter roadmap

JL Barrat, E Del Gado, SU Egelhaaf… - Journal of Physics …, 2023 - iopscience.iop.org
Soft materials are usually defined as materials made of mesoscopic entities, often self-
organised, sensitive to thermal fluctuations and to weak perturbations. Archetypal examples …

Biophysical determinants for the viscosity of concentrated monoclonal antibody solutions

I Mosca, K Pounot, C Beck, L Colin… - Molecular …, 2023 - ACS Publications
Monoclonal antibodies (mAbs) are particularly relevant for therapeutics due to their high
specificity and versatility, and mAb-based drugs are hence used to treat numerous diseases …

Copper drives prion protein phase separation and modulates aggregation

MJ do Amaral, S Mohapatra, AR Passos… - Science …, 2023 - science.org
Prion diseases are characterized by prion protein (PrP) transmissible aggregation and
neurodegeneration, which has been linked to oxidative stress. The physiological function of …