Endometrial cancer (EC) has four molecular subtypes with strong prognostic value and
therapeutic implications. The most common subtype (NSMP; No Specific Molecular Profile) …

Purpose: The clinical significance of the p53-abnormal (p53abn) molecular subtype in stage
I low-grade endometrioid endometrial carcinoma (EEC) is debated. We aimed to review …

Loss-of-function mutations in the tumour suppressor APC are an initial step in intestinal
tumorigenesis 1, 2. APC-mutant intestinal stem cells outcompete their wild-type neighbours …

Cancer is an evolutionary process involving the accumulation of diverse somatic mutations
and clonal evolution over time. Phylogenetic inference from samples obtained from an …

Phylogenetic trees based on copy number profiles from multiple samples of a patient are
helpful to understand cancer evolution. Here, we develop a new maximum likelihood …

Whole‐genome sequencing (WGS) of circulating tumour DNA (ctDNA) is now a clinically
important biomarker for predicting therapy response, disease burden and disease …

Cancer cells often exhibit DNA copy number aberrations and can vary widely in their ploidy.
Correct estimation of the ploidy of single-cell genomes is paramount for downstream …

High-grade serous ovarian carcinoma (HGSOC) is characterised by poor outcome and
extreme chromosome instability (CIN). Therapies targeting centrosome amplification (CA), a …

ABSTRACT Motivation Intra-Tumor Heterogeneity (ITH) is a hallmark of cancer. ITH
influences evolution of tumors and hence also affects patients survival. There are several …

Chromosomal instability is a characteristic hallmark of cancer. It is providing part of the
genomic variation that makes cancer so heterogeneous and difficult to treat. Consequently …