Anticancer strategies involving the vasculature
VL Heath, R Bicknell - Nature reviews Clinical oncology, 2009 - nature.com
The growth and metastasis of solid tumors critically depends on their ability to develop their
own blood supply, a process known as tumor angiogenesis. Over the past decade much …
own blood supply, a process known as tumor angiogenesis. Over the past decade much …
Angiogenesis biomarkers and their targeting ligands as potential targets for tumor angiogenesis
M Mashreghi, H Azarpara, MR Bazaz… - Journal of cellular …, 2018 - Wiley Online Library
Angiogenesis is known as one of the hallmarks in cancer which could play a key role in
providing oxygen and nutrients for tumor cells. It has been shown that tumor cannot grow …
providing oxygen and nutrients for tumor cells. It has been shown that tumor cannot grow …
[HTML][HTML] A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis
Limited clinical benefits derived from anti-VEGF therapy have driven the identification of new
targets involved in tumor angiogenesis. Here, we report an integrative meta-analysis to …
targets involved in tumor angiogenesis. Here, we report an integrative meta-analysis to …
Accelerated recruitment of new brain development genes into the human genome
How the human brain evolved has attracted tremendous interests for decades. Motivated by
case studies of primate-specific genes implicated in brain function, we examined whether or …
case studies of primate-specific genes implicated in brain function, we examined whether or …
Tumor-derived circulating endothelial cell clusters in colorectal cancer
Clusters of tumor cells are often observed in the blood of cancer patients. These structures
have been described as malignant entities for more than 50 years, although their …
have been described as malignant entities for more than 50 years, although their …
De novo transcriptome assembly of drought tolerant CAM plants, Agave deserti and Agave tequilana
Background Agaves are succulent monocotyledonous plants native to xeric environments of
North America. Because of their adaptations to their environment, including crassulacean …
North America. Because of their adaptations to their environment, including crassulacean …
Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome
LE Reynolds, AR Watson, M Baker, TA Jones… - Nature, 2010 - nature.com
Down's syndrome (DS) is a genetic disorder caused by full or partial trisomy of human
chromosome 21 and presents with many clinical phenotypes including a reduced incidence …
chromosome 21 and presents with many clinical phenotypes including a reduced incidence …
Identification and angiogenic role of the novel tumor endothelial marker CLEC14A
Tumor endothelial markers (TEMs) that are highly expressed in human tumor vasculature
compared with vasculature in normal tissue hold clear therapeutic potential. We report that …
compared with vasculature in normal tissue hold clear therapeutic potential. We report that …
Netrin-1 mediates early events in pancreatic adenocarcinoma progression, acting on tumor and endothelial cells
L Dumartin, C Quemener, H Laklai, J Herbert… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) is one of the most
lethal cancers. It is characterized by substantial tumor cell invasion and early-stage …
lethal cancers. It is characterized by substantial tumor cell invasion and early-stage …
[HTML][HTML] Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation-promoting factors
H Sheldon, M Andre, JA Legg, P Heal… - The FASEB …, 2009 - ncbi.nlm.nih.gov
This study aimed to further elucidate the function of Roundabout proteins in endothelium.
We show that both Robo1 and Robo4 are present in human umbilical vein endothelial cells …
We show that both Robo1 and Robo4 are present in human umbilical vein endothelial cells …