Pandemic of coronavirus disease (COVID-19) is still pressing the healthcare systems worldwide. Thus far, the lack of available COVID-19-targeted treatments has led scientists to …
M Spanakis, P Ioannou, S Tzalis, V Papakosta… - Journal of Clinical …, 2022 - mdpi.com
The modulation of the pharmacological action of drugs due to drug-drug interactions (DDIs) is a critical issue in healthcare. The aim of this study was to evaluate the prevalence and the …
Background Chronic kidney disease (CKD) is a challenging global health problem with increasing prevalence worldwide. Concurrence of CKD and comorbidities results in the use …
M Spanakis, M Melissourgaki, G Lazopoulos… - Pharmaceutics, 2021 - mdpi.com
Background: Drug interactions represent a major issue in clinical settings, especially for critically ill patients such as those with cardiovascular disease (CVD) who require …
J Moryousef, É Bortolussi-Courval… - … Journal of Kidney …, 2022 - journals.sagepub.com
Background: End-stage kidney disease patients on dialysis have a substantial risk of polypharmacy due their propensity for comorbidity and contact with the health care system …
S Cho, H Jo, YJ Hwang, C Kim, YH Jo… - Food and Chemical …, 2024 - Elsevier
Nonclinical studies involve in vitro, in silico, and in vivo experiments to assess the toxicokinetics, toxicology, and safety pharmacology of drugs according to regulatory …
M Provenzano, L Hu, E Tringali, M Senatore, R Talarico… - Biomedicines, 2024 - mdpi.com
Nephrology is an ever-evolving field of medicine. The importance of such a discipline is related to the high clinical impact of kidney disease. In fact, abnormalities of kidney function …
M Spanakis, P Ioannou, S Tzalis, F Chouzouri… - … in Respiratory Medicine, 2023 - mdpi.com
Highlights What are the main findings? Patients admitted for hospitalization in Greece due to respiratory disorders are patients with multimorbidity, polypharmacy, and a high prevalence …