Immunopathogenesis of Behcet's disease

B Tong, X Liu, J Xiao, G Su - Frontiers in immunology, 2019 - frontiersin.org
Behcet's disease (BD) is a chronic systemic inflammatory vasculitis of unknown etiology
characterized by recurrent episodes of oral aphthous ulcers, genital ulcers, skin lesions …

Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis

Z Zhong, G Su, A Kijlstra, P Yang - Progress in retinal and eye research, 2021 - Elsevier
Uveitis is a group of diseases characterized by intraocular inflammation, of which some are
driven by autoinflammatory or autoimmune responses, such as Vogt-Koyanagi-Harada …

Cytokines that modulate the differentiation of Th17 cells in autoimmune uveitis

K Guo, X Zhang - Journal of immunology research, 2021 - Wiley Online Library
Increasing evidence has suggested that T helper 17 (Th17) cells play a central role in the
pathogenesis of ocular immune disease. The association between pathogenic Th17 cells …

Effect of interferon alfa-2a treatment on adaptive and innate immune systems in patients with Behçet disease uveitis

O Albayrak, M Oray, F Can, GU Kirimli… - … & visual science, 2019 - iovs.arvojournals.org
Purpose: To investigate the effect of interferon alfa-2a on T regulatory (Treg) cells, T helper
17 (Th17) cells, and expression of Toll-like receptors (TLRs) in Behçet disease (BD) patients …

The role of Th17 cells in the pathogenesis of Behcet's disease

Y Nanke, T Yago, S Kotake - Journal of clinical medicine, 2017 - mdpi.com
Behcet's disease (BD) is a polysymptomatic and recurrent systemic vasculitis with a chronic
course and unknown cause. The pathogenesis of BD has not been fully elucidated; …

T cells in ocular autoimmune uveitis: Pathways and therapeutic approaches

M Zhang, X Zhang - International Immunopharmacology, 2023 - Elsevier
Autoimmune uveitis is a non-infectious intraocular condition that affects the uveal tract of the
eye and threatens vision if not treated properly. Increasing evidence suggests that activated …

Interferon-α2a induces CD4+ T cell apoptosis and suppresses Th1/Th17 responses via upregulating IRF1-mediated PDL1 expression in dendritic cells from Behcet's …

Y Zhu, Q Yu, G Su, N Shao, J Feng, X Luo, C Zhou… - Clinical …, 2023 - Elsevier
Recombinant interferon-α2a (IFNα2a) has been widely used in the treatment of Behcet's
uveitis (BU). However, the mechanism underlying its effects remains poorly understood. In …

[PDF][PDF] Behçet's syndrome: a critical digest of the 2013-2014 literature

G Hatemi, E Seyahi, I Fresko, R Talarico… - Clin Exp …, 2014 - researchgate.net
This review focuses on the recent research on the epidemiology, outcome measures,
immunopathogenesis, genetics, clinical manifestations and management of Behçet's …

Methylation status of interleukin-6 gene promoter in patients with behcet's disease

S Alipour, E Sakhinia, A Khabbazi, N Samadi… - Reumatologia clinica, 2020 - Elsevier
Background IL-6 mRNA expression is significantly high in many autoimmune diseases such
as Behçet's disease; this is often related with more aggressive phenotypes. Nevertheless …

Hypermethylation of IL‐10 gene is responsible for its low mRNA expression in Behçet's disease

S Alipour, M Nouri, A Khabbazi… - Journal of cellular …, 2018 - Wiley Online Library
Abstract Interleukin‐10 (IL‐10), produced generally by monocyte, T helper type 2 (Th2), and
regulatory T cells (Treg), plays a central role in controlling inflammatory responses and …