In the almost 70 years since the first hints of its existence, the phosphoinositide,
phosphatidyl-D-myo-inositol 4, 5-bisphosphate has been found to be central in the …

The number of double bonds in the acyl chains of membrane lipids varies tremendously at
all scales of life, from the organism level to the subcellular level, where differences in lipid …

Phosphorylation is the most common module of cellular signalling pathways. The dynamic
nature of phosphorylation, which is conferred by the balancing acts of kinases and …

Cellular lipids have an enormous diversity in their chemical structures, which affect the
physicochemical properties of lipids and membranes, as well as their regulatory roles on …

Mammalian cells utilize over 1000 different lipid species to maintain cell and organelle
membrane properties, control cell signaling and processes, and store energy. Lipid …

Phosphatidylinositol (PI) is the precursor lipid for the minor phosphoinositides (PPIns), which
are critical for multiple functions in all eukaryotic cells. It is poorly understood how …

CDS enzymes (CDS1 and 2 in mammals) convert phosphatidic acid (PA) to CDP-DG, an
essential intermediate in the de novo synthesis of PI. Genetic deletion of CDS2 in primary …

Phosphoinositides (PIPn) in mammalian tissues are enriched in the stearoyl/arachidonoyl
acyl chain species (“C38: 4”), but its functional significance is unclear. We have used …

Biological membranes are highly dynamic, in particular due to the constant exchange of
vesicles between the different compartments of the cell. In addition, the dynamic nature of …

Diacylglycerol kinase-ε (DGKε) catalyzes phosphorylation of diacylglycerol to phosphatidic
acid with a unique specificity toward 1-stearoyl-2-arachidonoyl-sn-glycerol, which is a …