Rapid progress in identifying biomarkers that are hallmarks of disease has increased
demand for high-performance detection technologies. Implementation of electrochemical …

It has been known for decades that it is possible to detect small amounts of extracellular
nucleic acids in plasma and serum of healthy and diseased human beings. The unequivocal …

Background: Circulating RNA in plasma/serum is an emerging field for noninvasive
molecular diagnosis. Because RNA is widely thought to be labile in the circulation, we …

Despite its early promise as a diagnostic and prognostic tool, gene expression profiling
remains cost-prohibitive and challenging to implement in a clinical setting. Here, we …

Background: As RNA is labile, we investigated whether circulating RNA in human plasma
may be present in a particle-associated form. Methods: Blood was collected from 27 healthy …

Pancreatic cancer remains difficult to treat and has a high mortality rate. It is difficult to
diagnose early, mainly due to the lack of screening imaging modalities and specific …

Circulating nucleic acids are found in free form in body fluids and may serve as minimally
invasive tools for cancer diagnosis and prognosis. Only a few studies have investigated the …

BACKGROUND: The detection of circulating nucleic acids has long been explored for the
non-invasive diagnosis of a variety of clinical conditions. In earlier studies, detection of …

Telomerase, a critical enzyme responsible for continuous cell growth, is repressed in most
somatic cells except proliferating progenitor cells and activated lymphocytes, and activated …

Since the discovery of circulating nucleic acids in plasma in 1948, many diagnostic
applications have emerged. For example, diagnostic and prognostic potentials of circulating …