Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

N-terminal acetylation (Nt-acetylation) is a widespread protein modification among
eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino …

Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …

The majority of eukaryotic proteins are subjected to N-terminal acetylation (Nt-acetylation),
catalysed by N-terminal acetyltransferases (NATs). Recently, the structure of an NAT …

We have identified two families with a previously undescribed lethal X-linked disorder of
infancy; the disorder comprises a distinct combination of an aged appearance, craniofacial …

Legumes and a few other plant species can establish a symbiotic relationship with nitrogen-
fixing rhizobia, which enables them to survive in a nitrogen-deficient environment. During …

Cancer cells interact with endothelial cells during the process of metastatic spreading. Here,
we use a small interfering RNA screen targeting Rho GTPases in cancer cells to identify …

MicroRNAs (miRNA) have emerged as key players in carcinogenesis. Here, we investigated
the role of miR-137 in the pathogenesis of lung cancer. The downregulation of miR-137 in …

The human N-terminal acetyltransferases (NATs) catalyze the transfer of acetyl moieties to
the N-termini of 80–90% of all human proteins. Six NAT types are present in humans, NatA …

The X-linked lethal Ogden syndrome was the first reported human genetic disorder
associated with a mutation in an N-terminal acetyltransferase (NAT) gene. The affected …