Abstract UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …

Exposure to low ambient temperature imposes great challenge to human health.
Epidemiological evidence has noted significantly elevated emergency admission and …

Objective Cold exposure provokes cardiac remodeling and cardiac dysfunction. Autophagy
participates in cold stress-induced cardiovascular dysfunction. This study was designed to …

Pulmonary hypertension (PH) is caused by chronic hypoxia that induces the migration and
proliferation of pulmonary arterial smooth muscle cells (PASMCs), eventually resulting in …

冬季持续低温引起的冷应激是降低北方畜牧业经济效益和动物福利的重要因素,
可诱导动物产生炎症反应和氧化应激危害机体健康. 热休克蛋白作为体内重要的分子伴侣蛋白 …

Sepsis is characterized by systematic inflammation and contributes to cardiac dysfunction.
This study was designed to examine the effect of protein kinase B (Akt) activation on …

Autophagy, a conservative degradation process for long-lived and damaged proteins,
participates in a cascade of biological processes including aging. A number of autophagy …

Cold stress prompts an increased prevalence of cardiovascular morbidity yet the underneath
machinery remains unclear. Oxidative stress and autophagy appear to contribute to cold …

Objectives: To study the reversibility of cold-induced cardiac hypertrophy and the role of
autophagy in this process. Background: Chronic exposure to cold is known to cause cardiac …

Abstract Mitochondrial aldehyde dehydrogenase 2 (ALDH2) was demonstrated to play
cardioprotective roles in cardiovascular diseases. Nonetheless, little is known about the …