The superfamily of serine protease inhibitors (SERPINs) are a class of inhibitors that utilise a
dynamic conformational change to trap and inhibit their target enzymes. Their powerful …

Posttraumatic coagulopathy involves disruption of both the coagulation and fibrinolytic
pathways secondary to tissue damage, hypotension, and inflammatory upregulation. This …

The molecular pathomechanisms in the majority of patients suffering from acute or
progressive sensorineural hearing loss cannot be determined yet. The size and the complex …

Traumatic brain injury (TBI) due to a direct blow or penetrating injury to the head damages
the brain tissue and affects brain function. Primary and secondary damage to the brain …

Background Platelets are a key component of massive transfusion in treating actively
bleeding patients. While optimized for prophylactic transfusions, the effectiveness of the …

Background Platelet transfusion is challenging in emergency medicine because of short
platelet shelf life and stringent storage conditions. Platelet‐derived extracellular vesicles …

Methods This was a double-blind, placebo-controlled, randomized trial, evaluating VTE
rates in two groups: ASA+ statin (Experimental) and identical placebos (Control). Injured …

Plasminogen activator inhibitor-1 (PAI-1) antagonists are known for their neuroprotective
effects. In this study, it was aimed to investigate the possible protective effects of PAI-1 …

Background: Burns represent a serious health problem, associated with multiple-organ
failure, prolonged hospitalization, septic complications, and increased rate of mortality. The …

Antibody mediated strategies for protein biomarker detection are common, but may limit
discovery. We hypothesized that the use of antibody-free proteomics is feasible for detecting …