CircRNAs: role in human diseases and potential use as biomarkers

L Verduci, E Tarcitano, S Strano, Y Yarden… - Cell death & …, 2021 - nature.com
Circular RNAs (circRNAs) are a class of endogenous RNAs characterized by a covalent
loop structure. In comparison to other types of RNAs, the abundance of circRNAs is relatively …

[HTML][HTML] Review on circular RNAs and new insights into their roles in cancer

X Tang, H Ren, M Guo, J Qian, Y Yang, C Gu - … and structural biotechnology …, 2021 - Elsevier
Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA
molecules derived from exonic or intronic sequences by precursor mRNA back-splicing …

The interplay between m6A RNA methylation and noncoding RNA in cancer

S Ma, C Chen, X Ji, J Liu, Q Zhou, G Wang… - Journal of hematology & …, 2019 - Springer
Abstract N6-methyladenosine (m6A) methylation, one of the most common RNA
modifications, has been reported to execute important functions that affect normal life …

Circular RNAs function as ceRNAs to regulate and control human cancer progression

Y Zhong, Y Du, X Yang, Y Mo, C Fan, F Xiong, D Ren… - Molecular cancer, 2018 - Springer
Circular RNAs (circRNAs) are connected at the 3′ and 5′ ends by exon or intron
cyclization, forming a complete ring structure. circRNA is more stable and conservative than …

Circular RNA and its mechanisms in disease: from the bench to the clinic

B Han, J Chao, H Yao - Pharmacology & therapeutics, 2018 - Elsevier
The emerging recognition of the functional roles of circular RNAs (circRNAs) has given rise
to a new perspective regarding our understanding of cellular physiology and disease …

Going circular: history, present, and future of circRNAs in cancer

G Pisignano, DC Michael, TH Visal, R Pirlog… - Oncogene, 2023 - nature.com
To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …

Circular RNAs in cancer: opportunities and challenges in the field

LS Kristensen, TB Hansen, MT Venø, J Kjems - Oncogene, 2018 - nature.com
Circular RNA (circRNA) is a novel member of the noncoding cancer genome with distinct
properties and diverse cellular functions, which is being explored at a steadily increasing …

[HTML][HTML] Circular RNAs in cancer

DH Bach, SK Lee, AK Sood - Molecular Therapy-Nucleic Acids, 2019 - cell.com
Circular RNAs (circRNAs) are a class of single-stranded closed RNA molecules that are
formed by precursor mRNA back-splicing or skipping events of thousands of genes in …

The circ RNA–micro RNA code: emerging implications for cancer diagnosis and treatment

L Verduci, S Strano, Y Yarden… - Molecular oncology, 2019 - Wiley Online Library
Circular RNA s (circ RNA s) comprise an emerging new class of endogenous RNA s
expressed abundantly by the eukaryotic transcriptome. They are characterized by a …

Role of circular RNAs in brain development and CNS diseases

SL Mehta, RJ Dempsey, R Vemuganti - Progress in neurobiology, 2020 - Elsevier
In mammals, many classes of noncoding RNAs (ncRNAs) are expressed at a much higher
level in the brain than in other organs. Recent studies have identified a new class of ncRNAs …