There exists a marked circadian variation for several bone markers (BM), which is influenced
by endogenous as well as exogenous factors including hormones, physical activity, and …

Numerous studies have reported the clinical value of alkaline phosphatase (ALP) and its
bone-specific isoforms (bone-specific alkaline phosphatase (BAP)) in breast cancer. The …

A review and discussion of new knowledge on the structure and function of mammalian
alkaline phosphatases (APs) gained over the last 25 years. It covers:* The structure …

This work addresses a biosensor combining the immunomagnetic separation and the
electrochemical biosensing based on the intrinsic ALP activity of the exosomes. This …

BACKGROUND: Bone metastases are prevalent among patients with advanced solid
tumors. Metastatic bone disease alters bone homeostasis, resulting in reduced bone …

Biochemical markers of bone turnover provide insight into ongoing rates of skeletal
metabolism and tumor–bone interactions in patients with malignant bone disease. This …

Bone formation markers bone-specific alkaline phosphatase and osteocalcin are used in
many clinical situations. Therefore, we calculated reference intervals for the two markers and …

Bone metastases profoundly perturb normal bone remodeling. Biochemical markers of bone
turnover have been shown to reflect these tumor-induced changes in bone remodeling and …

Bone metastases are characterized by increased osteoblastic and/or osteolytic processes
depending on the tumor type. The altogether destructive effect of metastasis formation …

Purpose Bone turnover markers (BTM) are gaining ground in clinical practice but to fully use
their potential there is a need for establishing valid reference intervals (RI). Consequently …