Melanin synthesis involves the successful coordination of metabolic pathways across
multiple intracellular compartments including the melanosome, mitochondria, ER/Golgi, and …

Melanoma exhibits numerous transcriptional cell states including neural crest-like cells as
well as pigmented melanocytic cells. How these different cell states relate to distinct …

Mitochondria regulate several physiological functions through mitochondrial Ca2+
dynamics. However, role of mitochondrial Ca2+ signaling in melanosome biology remains …

Skin aging is a complex biological process involving intrinsic and extrinsic factors. Skin
aging contains alterations at the tissue, cellular, and molecular levels. Currently, there is …

Stromal Interaction Molecule1 (STIM1) is an endoplasmic reticulum membrane-localized
calcium (Ca 2+) sensor that plays a critical role in the store-operated Ca 2+ entry (SOCE) …

The biochemical pathway regulating the synthesis of yellow/red pheomelanin is less well
characterized than the synthesis of black/brown eumelanin. Inhibitor of gold (IG phenotype) …

The ultraviolet (UV) radiation triggers a pigmentation response in human skin, wherein,
melanocytes rapidly activate divergent maturation and proliferation programs. Using single …

Background Lipid metabolism has essential roles in skin barrier formation and the regulation
of skin inflammation. Lipid homeostasis regulates skin melanogenesis, although the …

Melanin, a light and free radical absorbing pigment, is produced in melanocyte cells that are
found in skin, but also in hair follicles, eyes, the inner ear, heart, brain and other organs …

Mitochondria are versatile organelles that regulate several physiological functions. Many
mitochondria-controlled processes are driven by mitochondrial Ca 2+ signaling. However …