Compulsion is a cardinal symptom of drug addiction (severe substance use disorder).
However, compulsion is observed in only a small proportion of individuals who repeatedly …

It is becoming clearer how neurobiological mechanisms generate 'liking'and
'wanting'components of food reward. Mesocorticolimbic mechanisms that enhance …

This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …

The striatum integrates excitatory inputs from the cortex and the thalamus to control diverse
functions. Although the striatum is thought to consist of sensorimotor, associative and limbic …

We revisit our hypothesis that drug addiction can be viewed as the endpoint of a series of
transitions from initial voluntarily drug use to habitual, and ultimately compulsive drug use …

Progressive loss of the ascending dopaminergic projection in the basal ganglia is a
fundamental pathological feature of Parkinson's disease. Studies in animals and humans …

Recent behavioral studies in both humans and rodents have found evidence that
performance in decision-making tasks depends on two different learning processes; one …

Addiction is associated with neuroplasticity in the corticostriatal brain circuitry that is
important for guiding adaptive behaviour. The hierarchy of corticostriatal information …

The ability to establish behaviorally what psychological capacity an animal is deploying—to
discern accurately what an animal is doing—is key to functional analyses of the brain. Our …

For goal-directed behaviour it is critical that we can both select the appropriate action and
learn to modify the underlying movements (for example, the pitch of a note or velocity of a …