Engineered hydrogels for mechanobiology
Cells' local mechanical environment can be as important in guiding cellular responses as
many well-characterized biochemical cues. Hydrogels that mimic the native extracellular …
many well-characterized biochemical cues. Hydrogels that mimic the native extracellular …
FGF/FGFR signaling in health and disease
Y Xie, N Su, J Yang, Q Tan, S Huang, M Jin… - Signal transduction and …, 2020 - nature.com
Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …
signaling has crucial roles in a multitude of processes during embryonic development and …
Cholesterol 25‐Hydroxylase inhibits SARS‐CoV‐2 and other coronaviruses by depleting membrane cholesterol
Abstract Coronavirus disease 2019 (COVID‐19) is caused by SARS‐CoV‐2 and has spread
across the globe. SARS‐CoV‐2 is a highly infectious virus with no vaccine or antiviral …
across the globe. SARS‐CoV‐2 is a highly infectious virus with no vaccine or antiviral …
[HTML][HTML] The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity
CC Bain, AS MacDonald - Mucosal immunology, 2022 - Elsevier
The last decade has been somewhat of a renaissance period for the field of macrophage
biology. This renewed interest, combined with the advent of new technologies and …
biology. This renewed interest, combined with the advent of new technologies and …
The history and mystery of alveolar epithelial type II cells: focus on their physiologic and pathologic role in lung
Alveolar type II (ATII) cells are a key structure of the distal lung epithelium, where they exert
their innate immune response and serve as progenitors of alveolar type I (ATI) cells …
their innate immune response and serve as progenitors of alveolar type I (ATI) cells …
The cellular and physiological basis for lung repair and regeneration: past, present, and future
The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …
Animal and translational models of SARS-CoV-2 infection and COVID-19
COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical
community is in a race to define and develop effective preventions and treatments. The …
community is in a race to define and develop effective preventions and treatments. The …
Engineered materials for organoid systems
Organoids are 3D cell culture systems that mimic some of the structural and functional
characteristics of an organ. Organoid cultures provide the opportunity to study organ-level …
characteristics of an organ. Organoid cultures provide the opportunity to study organ-level …
Modeling neoplastic disease with spheroids and organoids
Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …
components contribute to the development, progression, and metastasization of disease …
[HTML][HTML] Androgen signaling regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men
RM Samuel, H Majd, MN Richter, Z Ghazizadeh… - Cell Stem Cell, 2020 - cell.com
SARS-CoV-2 infection has led to a global health crisis, and yet our understanding of the
disease and potential treatment options remains limited. The infection occurs through …
disease and potential treatment options remains limited. The infection occurs through …