Recent findings have demonstrated that mitochondria can be transferred between cells to
control metabolic homeostasis. Although the mitochondria of brown adipocytes comprise a …

Mitochondrial uncoupling protein 1 (UCP1) is the crucial mechanistic component of heat
production in classical brown fat and the newly identified beige or brite fat. Thermogenesis …

Objective Classical ATP-independent non-shivering thermogenesis enabled by uncoupling
protein 1 (UCP1) in brown adipose tissue (BAT) is activated, but not essential for survival, in …

Altered methionine metabolism is associated with weight gain in obesity. The methionine
adenosyltransferase (MAT), catalyzing the first reaction of the methionine cycle, plays an …

Summary Although uncoupling protein 1 (UCP1) is established as a major contributor to
adipose thermogenesis, recent data have illustrated an important role for alternative …

Thermogenic adipocytes generate heat to maintain body temperature against hypothermia
in response to cold. Although tight regulation of thermogenesis is required to prevent energy …

Obesity and type 2 diabetes cause a loss in brown adipose tissue (BAT) activity, but the
molecular mechanisms that drive BAT cell remodeling remain largely unexplored. Using a …

Background MicroRNAs (miRNAs) are a family of short non-coding RNA molecules and play
important roles in various biological processes. However, knowledge of the expression …

The ability of alternative splicing mechanisms to control gene expression is increasingly
being recognized as relevant for adipose tissue function. The expression of SF3B1, a key …

The recruitment of thermogenic brite adipocytes within white adipose tissue attenuates
obesity and metabolic comorbidities, arousing interest in understanding the underlying …