Cisplatin, oxaliplatin, paclitaxel, vincristine and bortezomib are some of the most effective
drugs successfully employed (alone or in combinations) as first-line treatment for common …

Global oxycodone consumption has increased sharply during the last two decades, and, in
2008, oxycodone consumption surpassed that of morphine. As oxycodone was synthesized …

Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating, and dose-
limiting side effect of many chemotherapy regimens yet has limited treatments due to …

This paper is the thirty-seventh consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2014 …

Despite a century of research on the physiology/pathophysiology of the spinal cord in
chronic pain condition, the properties of the spinal cord were rarely studied at the large …

Vincristine is a commonly used chemotherapeutic drug that can produce painful peripheral
neuropathy. The chemokine (CXC motif) ligand 1 (CXCL1) and its receptor chemokine (CXC …

Over the past three decades the research on GABA B receptor biology and pharmacology in
pain processing has been a fascinating experience. Norman Bowery's fundamental …

Introduction Optimal pain management is crucial to the postoperative recovery process. We
aimed to evaluate the efficacy and safety of intravenous oxycodone with intravenous …

Painful experiences are multilayered, composed of sensory, affective, cognitive and
behavioral facets. Whereas it is well accepted that the development of chronic pain is due to …

Antimicrotubulin chemotherapeutic agents, including plant-derived vincaalkaloids such as
vincristine, can cause peripheral neuropathic pain. Exogenously activated heme oxygenase …