Flow chemistry has unlocked a world of possibilities for the synthetic community, but the idea
that it is a mysterious “black box” needs to go. In this review, we show that several of the …

Since their structural elucidation in 1935, the introduction and substitution of functional
groups and the modification of the steroidal scaffolds have been a fertile ground of research …

Flow processing offers many opportunities to optimize reactions in a rapid and automated
manner, yet often requires relatively large quantities of input materials. To combat this, the …

As organic chemistry becomes an increasingly data-rich field, there is a need for methods to
rapidly build and parameterize models for further development. We demonstrate the …

Synthetic chemistry has progressively integrated advanced optimization methods. While
traditional approaches often prioritize continuous variables, the significance of discrete …

Herein, we report a simple and comprehensive mixed variable optimization strategy which
enabled the development of ultra-fast formal [3+ 3]-cycloadditions of 1, 3-dicarbonyl …

We present a workflow that uses digital tools to optimise the experimental approach and
maximise the efficiency in achieving the required process parameters for a desired set of …

In modern pharmaceutical research, the demand for expeditious development of synthetic
routes to active pharmaceutical ingredients (APIs) has led to a paradigm shift towards data …

Low oxygen levels are critical for a long range of chemical transformations carried out in
both flow and batch chemistry. Here, we present an inline continuous flow degassing system …

An atom‐economical sequential‐flow synthesis of donepezil, a widely prescribed drug for
Alzheimer's disease, was accomplished using inexpensive, commercially available …