Renal cell-targeted drug delivery strategy for acute kidney injury and chronic kidney disease: a mini-review
D Liu, Y Du, FY Jin, XL Xu, YZ Du - Molecular Pharmaceutics, 2021 - ACS Publications
Kidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD),
have become a global public health concern associated with high morbidity, mortality, and …
have become a global public health concern associated with high morbidity, mortality, and …
Extracellular vesicles for ischemia/reperfusion injury-induced acute kidney injury: a systematic review and meta-analysis of data from animal models
XQ Li, JF Liu, H Liu, Y Meng - Systematic Reviews, 2022 - Springer
Background Acute kidney injury (AKI) induced by ischemia/reperfusion injury significantly
contribute to the burden of end-stage renal disease. Extracellular vesicles (EVs), especially …
contribute to the burden of end-stage renal disease. Extracellular vesicles (EVs), especially …
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability
M Wu, W Chen, M Miao, Q Jin, S Zhang, M Bai… - Clinical …, 2021 - portlandpress.com
Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney
disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD …
disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD …
Pericyte-mediated constriction of renal capillaries evokes no-reflow and kidney injury following ischaemia
F Freitas, D Attwell - Elife, 2022 - elifesciences.org
Acute kidney injury is common, with~ 13 million cases and 1.7 million deaths/year
worldwide. A major cause is renal ischaemia, typically following cardiac surgery, renal …
worldwide. A major cause is renal ischaemia, typically following cardiac surgery, renal …
Pyruvate kinase M2 regulates kidney fibrosis through pericyte glycolysis during the progression from acute kidney injury to chronic kidney disease
Y Chen, X Bai, J Chen, M Huang, Q Hong… - Cell …, 2024 - Wiley Online Library
We aimed to investigate the role of renal pericyte pyruvate kinase M2 (PKM2) in the
progression of acute kidney injury (AKI) to chronic kidney disease (CKD). The role of PKM2 …
progression of acute kidney injury (AKI) to chronic kidney disease (CKD). The role of PKM2 …
The role of TRPC6 in renal ischemia/reperfusion and cellular hypoxia/reoxygenation injuries
X Hou, M Huang, X Zeng, Y Zhang, A Sun… - Frontiers in Molecular …, 2021 - frontiersin.org
Renal ischemia/reperfusion (I/R), a major cause of acute kidney injury (AKI), is a serious
clinical event in patients during post-renal transplantation. I/R is associated with renal …
clinical event in patients during post-renal transplantation. I/R is associated with renal …
Increased Ca2+ transport across the mitochondria-associated membranes by Mfn2 inhibiting endoplasmic reticulum stress in ischemia/reperfusion kidney injury
S Wang, X Sang, S Li, W Yang, S Wang, H Chen… - Scientific Reports, 2023 - nature.com
Renal ischemia/reperfusion (I/R) injury, which leads to acute kidney injury (AKI), is a major
cause of morbidity and mortality in a variety of clinical situations. This study aimed to …
cause of morbidity and mortality in a variety of clinical situations. This study aimed to …
Whole-Body and Whole-Organ 3D Imaging of Hypoxia Using an Activatable Covalent Fluorescent Probe Compatible with Tissue Clearing
DM Sakamoto, I Tamura, B Yi, S Hasegawa, Y Saito… - ACS …, 2024 - ACS Publications
Elucidation of biological phenomena requires imaging of microenvironments in vivo.
Although the seamless visualization of in vivo hypoxia from the level of whole-body to single …
Although the seamless visualization of in vivo hypoxia from the level of whole-body to single …
Loss of FUT8 in renal tubules ameliorates ischemia‐reperfusion injury‐induced renal interstitial inflammation transition to fibrosis via the TLR3–NF‐κB pathway
Z Li, J Hao, L Li, N Shen, D Wang, N Wang… - The FASEB …, 2023 - Wiley Online Library
Renal ischemia‐reperfusion injury (IRI) is a common reason of acute kidney injury (AKI). AKI
can progress to chronic kidney disease (CKD) in some survivors. Inflammation is considered …
can progress to chronic kidney disease (CKD) in some survivors. Inflammation is considered …
Chronic central nervous system leptin administration attenuates kidney dysfunction and injury in a model of ischemia/reperfusion-induced acute kidney injury
JM do Carmo, JE Hall, LNS Furukawa… - American Journal …, 2024 - journals.physiology.org
In the present study, we examined whether chronic intracerebroventricular (ICV) leptin
administration protects against ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) …
administration protects against ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) …