Targeting immune cell checkpoints during sepsis
Immunosuppression is increasingly being recognized as one of the causes of increased
morbidity and mortality during sepsis. Both innate and adaptive immune system dysfunction …
morbidity and mortality during sepsis. Both innate and adaptive immune system dysfunction …
Treatment advances in sepsis and septic shock: modulating pro-and anti-inflammatory mechanisms
Sepsis is currently defined as a life-threatening organ dysfunction caused by a dysregulated
host response to infection, and it affects over 25 million people every year. Even more …
host response to infection, and it affects over 25 million people every year. Even more …
Immunotherapy: a promising approach to reverse sepsis-induced immunosuppression
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
responses to infection (Third International Consensus definition for Sepsis and septic …
responses to infection (Third International Consensus definition for Sepsis and septic …
The biology of natural killer cells during sepsis
Natural killer (NK) cells are large granular lymphocytes largely recognized for their
importance in tumour surveillance and the host response to viral infections. However, as the …
importance in tumour surveillance and the host response to viral infections. However, as the …
IL7 and IL7 Flt3L co-expressing CAR T cells improve therapeutic efficacy in mouse EGFRvIII heterogeneous glioblastoma
Chimeric antigen receptor (CAR) T cell therapy in glioblastoma faces many challenges
including insufficient CAR T cell abundance and antigen-negative tumor cells evading …
including insufficient CAR T cell abundance and antigen-negative tumor cells evading …
[HTML][HTML] Glutamine promotes O-GlcNAcylation of G6PD and inhibits AGR2 S-glutathionylation to maintain the intestinal mucus barrier in burned septic mice
D Wu, S Su, X Zha, Y Wei, G Yang, Q Huang, Y Yang… - Redox Biology, 2023 - Elsevier
Mucus forms the first line of defence of the intestinal mucosa barrier, and mucin is its core
component. Glutamine is a vital energy substance for goblet cells; it can promote mucus …
component. Glutamine is a vital energy substance for goblet cells; it can promote mucus …
Glutamine sustains energy metabolism and alleviates liver injury in burn sepsis by promoting the assembly of mitochondrial HSP60-HSP10 complex via SIRT4 …
Y Yang, Q Chen, S Fan, Y Lu, Q Huang, X Liu… - Redox …, 2024 - Taylor & Francis
Burns and burn sepsis, characterized by persistent and profound hypercatabolism, cause
energy metabolism dysfunction that worsens organ injury and systemic disorders. Glutamine …
energy metabolism dysfunction that worsens organ injury and systemic disorders. Glutamine …
Frontline Science: Anti-PD-L1 protects against infection with common bacterial pathogens after burn injury
Burn patients are susceptible to infections due, in part, to immune dysfunction. Upregulation
of programmed death-1 (PD-1) receptor on T cells and programmed cell death ligand-1 (PD …
of programmed death-1 (PD-1) receptor on T cells and programmed cell death ligand-1 (PD …
Gut microbial changes and their contribution to post-burn pathology
ME Luck, CJ Herrnreiter, MA Choudhry - Shock, 2021 - journals.lww.com
Burn injuries are a common form of traumatic injury that leads to significant morbidity and
mortality worldwide. Burn injuries are characterized by inflammatory processes and …
mortality worldwide. Burn injuries are characterized by inflammatory processes and …
The effect of artesunate to reverse CLP-induced sepsis immunosuppression mice with secondary infection is tightly related to reducing the apoptosis of T cells via …
Y Yuan, L Hua, J Zhou, D Liu, F Ouyang, X Chen… - International …, 2023 - Elsevier
T cells play an important role in regulating immune system balance. Sepsis-associated
immunosuppression causes apoptosis of T cells and a decrease in their number. Previously …
immunosuppression causes apoptosis of T cells and a decrease in their number. Previously …