Finding the balance between over-and under-treatment of ductal carcinoma in situ (DCIS)

EJ Groen, LE Elshof, LL Visser, J Emiel… - The Breast, 2017 - Elsevier
With the widespread adoption of population-based breast cancer screening, ductal
carcinoma in situ (DCIS) has come to represent 20–25% of all breast neoplastic lesions …

Genome evolution in ductal carcinoma in situ: invasion of the clones

AK Casasent, M Edgerton… - The Journal of pathology, 2017 - Wiley Online Library
Ductal carcinoma in situ (DCIS) is the most frequently diagnosed early‐stage breast cancer.
Only a subset of patients progress to invasive ductal carcinoma (IDC), and this presents a …

Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer

EH Lips, T Kumar, A Megalios, LL Visser… - Nature …, 2022 - nature.com
Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and,
despite treatment, a small fraction (5–10%) of DCIS patients develop subsequent invasive …

Precancer atlas to drive precision prevention trials

A Spira, MB Yurgelun, L Alexandrov, A Rao, R Bejar… - Cancer research, 2017 - AACR
Cancer development is a complex process driven by inherited and acquired molecular and
cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality …

[HTML][HTML] Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort

IMM Lakeman, M Rodríguez-Girondo, A Lee… - Genetics in …, 2020 - Elsevier
Purpose We evaluated the performance of the recently extended Breast and Ovarian
Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA version 5) in a …

Characterization of organoid cultured human breast cancer

N Goldhammer, J Kim, V Timmermans-Wielenga… - Breast Cancer …, 2019 - Springer
Organoid cultures are increasingly used to model human cancers experimentally with a view
to tailoring personalized medicine and predicting drug responses. Breast cancer is no …

Genome-wide copy-number alterations in circulating tumor DNA as a novel biomarker for patients with high-grade serous ovarian cancer

L Paracchini, L Beltrame, T Grassi, A Inglesi… - Clinical Cancer …, 2021 - AACR
Purpose: High-grade serous epithelial ovarian cancer (HGS-EOC) is defined by high levels
of somatic copy-number alterations (SCNA) with marked spatial and temporal tumor …

DCIS and LCIS: are the risk factors for developing in situ breast cancer different?

J Timbres, K Kohut, M Caneppele, M Troy, MK Schmidt… - Cancers, 2023 - mdpi.com
Simple Summary Ductal carcinoma in situ (DCIS) is recognised as a precursor to invasive
breast cancer (IBC), while lobular carcinoma in situ (LCIS) is considered a risk factor for …

Skin diseases of the breast and nipple: benign and malignant tumors

RA Waldman, J Finch, JM Grant-Kels… - Journal of the American …, 2019 - Elsevier
The evaluation and management of dermatologic diseases of the breast and nipple requires
an understanding of the unique anatomy of the breast and nipple and an awareness of the …

Cis-eQTL-based trans-ethnic meta-analysis reveals novel genes associated with breast cancer risk

JD Hoffman, RE Graff, NC Emami, CG Tai… - PLoS …, 2017 - journals.plos.org
Breast cancer is the most common solid organ malignancy and the most frequent cause of
cancer death among women worldwide. Previous research has yielded insights into its …