Transcriptional control of ribosome biogenesis in yeast: links to growth and stress signals

D Shore, S Zencir, B Albert - Biochemical Society Transactions, 2021 - portlandpress.com
Ribosome biogenesis requires prodigious transcriptional output in rapidly growing yeast
cells and is highly regulated in response to both growth and stress signals. This minireview …

Nucleolar and ribosomal DNA structure under stress: yeast lessons for aging and cancer

E Matos-Perdomo, F Machín - Cells, 2019 - mdpi.com
Once thought a mere ribosome factory, the nucleolus has been viewed in recent years as an
extremely sensitive gauge of diverse cellular stresses. Emerging concepts in nucleolar …

Integrated TORC1 and PKA signaling control the temporal activation of glucose-induced gene expression in yeast

J Kunkel, X Luo, AP Capaldi - Nature communications, 2019 - nature.com
The growth rate of a yeast cell is controlled by the target of rapamycin kinase complex I
(TORC1) and cAMP-dependent protein kinase (PKA) pathways. To determine how TORC1 …

The diabetes gene JAZF1 is essential for the homeostatic control of ribosome biogenesis and function in metabolic stress

A Kobiita, S Godbersen, E Araldi, U Ghoshdastider… - Cell reports, 2020 - cell.com
The ability of pancreatic β-cells to respond to increased demands for insulin during
metabolic stress critically depends on proper ribosome homeostasis and function. Excessive …

Determining growth rates from bright-field images of budding cells through identifying overlaps

JMJ Pietsch, AF Muñoz, DYA Adjavon, I Farquhar… - Elife, 2023 - elifesciences.org
Much of biochemical regulation ultimately controls growth rate, particularly in microbes.
Although time-lapse microscopy visualises cells, determining their growth rates is …

Balanced activities of Hsp70 and the ubiquitin proteasome system underlie cellular protein homeostasis

A Jawed, CT Ho, T Grousl, A Shrivastava… - Frontiers in Molecular …, 2023 - frontiersin.org
To counteract proteotoxic stress and cellular aging, protein quality control (PQC) systems
rely on the refolding, degradation and sequestration of misfolded proteins. In …

Mechanisms coordinating ribosomal protein gene transcription in response to stress

S Zencir, D Dilg, MP Rueda, D Shore… - Nucleic acids …, 2020 - academic.oup.com
While expression of ribosomal protein genes (RPGs) in the budding yeast has been
extensively studied, a longstanding enigma persists regarding their co-regulation under …

TORC1 and PKA activity towards ribosome biogenesis oscillates in synchrony with the budding yeast cell cycle

P Guerra, LAPE Vuillemenot… - Journal of Cell …, 2022 - journals.biologists.com
Recent studies have revealed that the growth rate of budding yeast and mammalian cells
varies during the cell cycle. By linking a multitude of signals to cell growth, the highly …

mTOR signaling as a regulator of hematopoietic stem cell fate

H Fernandes, J Moura, E Carvalho - Stem Cell Reviews and Reports, 2021 - Springer
Blood is generated throughout life by continued proliferation and differentiation of
hematopoietic progenitors, while at the top of the hierarchy, hematopoietic stem cells (HSCs) …

Comparative Research: Regulatory Mechanisms of Ribosomal Gene Transcription in Saccharomyces cerevisiae and Schizosaccharomyces pombe

H Hirai, K Ohta - Biomolecules, 2023 - mdpi.com
Restricting ribosome biosynthesis and assembly in response to nutrient starvation is a
universal phenomenon that enables cells to survive with limited intracellular resources …