Recently, in silico techniques have gained tremendous popularity in the field of small
molecule drug discovery. The computational jobs include not only hit generation, lead …

Background Various bioactive aromatic compounds containing the indole nucleus showed
clinical and biological applications. Indole scaffold has been found in many of the important …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is distinctly infective and
there is an ongoing effort to find a cure for this pandemic. Flavonoids exist in many diets as …

The design and synthesis of a new series of indole-chalcone linked 1, 2, 3-triazole hybrids
via Cu (Ι)-catalyzed azide-alkyne cycloaddition is reported. All the compounds (2, 4a–4e and …

Background: The indole framework is considered as one of the privileged structures in the
area of medicinal chemistry and drug discovery because compounds containing this …

Chalcones have various biological effects, from immune boosting to anti-cancer and anti-
diabetic. Structurally modified chalcones (SMC) are clinically relevant for diabetes and …

In this study, we aimed to (i) synthesize new 2-methylindole analogs containing various
amino structures, pyrrolidine, piperidine, morpholine, and substituted phenyl groups through …

Tuberculosis (TB) has been considered as the highly chronic, contagious and infectious
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …

A series of chalcone analogues (1–15) were synthesized by Claisen-Schmidt condensation
in good yields (70–95%) and characterized by FT-IR, 1 H NMR and mass spectral methods …

Indole, an aza-heterocyclic scaffold, has been found one of the most privileged scaffolds in
heterocyclic chemistry and drug discovery. Efforts have been made to provide the complete …