Functionalizing DNA origami to investigate and interact with biological systems

GA Knappe, EC Wamhoff, M Bathe - Nature Reviews Materials, 2023 - nature.com
DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …

Prospects and challenges of dynamic DNA nanostructures in biomedical applications

T Tian, Y Li, Y Lin - Bone Research, 2022 - nature.com
The physicochemical nature of DNA allows the assembly of highly predictable structures via
several fabrication strategies, which have been applied to make breakthroughs in various …

A DNA origami rotary ratchet motor

AK Pumm, W Engelen, E Kopperger, J Isensee, M Vogt… - Nature, 2022 - nature.com
To impart directionality to the motions of a molecular mechanism, one must overcome the
random thermal forces that are ubiquitous on such small scales and in liquid solution at …

Therapeutic DNAzymes: from structure design to clinical applications

J Yan, M Ran, X Shen, H Zhang - Advanced Materials, 2023 - Wiley Online Library
Therapeutic DNAzymes have unceasingly intrigued the scientific community owing to their
prosperous gene regulation capability. The efficacy of DNAzymes against many types of …

A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns

Y Wang, I Baars, I Berzina, I Rocamonde-Lago… - Nature …, 2024 - nature.com
The clustering of death receptors (DRs) at the membrane leads to apoptosis. With the goal of
treating tumours, multivalent molecular tools that initiate this mechanism have been …

Harnessing a paper-folding mechanism for reconfigurable DNA origami

M Kim, C Lee, K Jeon, JY Lee, YJ Kim, JG Lee, H Kim… - Nature, 2023 - nature.com
The paper-folding mechanism has been widely adopted in building of reconfigurable
macroscale systems because of its unique capabilities and advantages in programming …

Challenges and perspectives of DNA nanostructures in biomedicine

A Keller, V Linko - Angewandte Chemie International Edition, 2020 - Wiley Online Library
DNA nanotechnology holds substantial promise for future biomedical engineering and the
development of novel therapies and diagnostic assays. The subnanometer‐level …

Photocleavable Ortho-Nitrobenzyl-Protected DNA Architectures and Their Applications

MP O'Hagan, Z Duan, F Huang, S Laps, J Dong… - Chemical …, 2023 - ACS Publications
This review article introduces mechanistic aspects and applications of photochemically
deprotected ortho-nitrobenzyl (ONB)-functionalized nucleic acids and their impact on …

DNA nanostructure-based nucleic acid probes: construction and biological applications

DX Wang, J Wang, YX Wang, YC Du, Y Huang… - Chemical …, 2021 - pubs.rsc.org
In recent years, DNA has been widely noted as a kind of material that can be used to
construct building blocks for biosensing, in vivo imaging, drug development, and disease …

Dynamic DNA nanotechnology: toward functional nanoscale devices

M DeLuca, Z Shi, CE Castro, G Arya - Nanoscale Horizons, 2020 - pubs.rsc.org
Dynamic DNA nanotechnology involves the creation of nanoscale devices made of DNA
whose primary function arises from their ability to undergo controlled motion or …