Targeting transcription factors in cancer—from undruggable to reality
JH Bushweller - Nature Reviews Cancer, 2019 - nature.com
Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …
mediate aberrant gene expression, including blockade of differentiation and cell death gene …
The ETS family of oncogenic transcription factors in solid tumours
Findings over the past decade have identified aberrant activation of the ETS transcription
factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene …
factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene …
The spatial landscape of progression and immunoediting in primary melanoma at single-cell resolution
Cutaneous melanoma is a highly immunogenic malignancy that is surgically curable at early
stages but life-threatening when metastatic. Here we integrate high-plex imaging, 3D high …
stages but life-threatening when metastatic. Here we integrate high-plex imaging, 3D high …
Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis
The therapeutic application of human induced pluripotent stem cells (hiPSCs) for cartilage
regeneration is largely hindered by the low yield of chondrocytes accompanied by …
regeneration is largely hindered by the low yield of chondrocytes accompanied by …
A convergence-based framework for cancer drug resistance
DJ Konieczkowski, CM Johannessen, LA Garraway - Cancer cell, 2018 - cell.com
Despite advances in cancer biology and therapeutics, drug resistance remains problematic.
Resistance is often multifactorial, heterogeneous, and prone to undersampling …
Resistance is often multifactorial, heterogeneous, and prone to undersampling …
Melanoma genome sequencing reveals frequent PREX2 mutations
Melanoma is notable for its metastatic propensity, lethality in the advanced setting and
association with ultraviolet exposure early in life. To obtain a comprehensive genomic view …
association with ultraviolet exposure early in life. To obtain a comprehensive genomic view …
A melanocyte lineage program confers resistance to MAP kinase pathway inhibition
CM Johannessen, LA Johnson, F Piccioni, A Townes… - Nature, 2013 - nature.com
Malignant melanomas harbouring point mutations (Val600Glu) in the serine/threonine-
protein kinase BRAF (BRAF (V600E)) depend on RAF–MEK–ERK signalling for tumour cell …
protein kinase BRAF (BRAF (V600E)) depend on RAF–MEK–ERK signalling for tumour cell …
Melanoma: from mutations to medicine
H Tsao, L Chin, LA Garraway… - Genes & …, 2012 - genesdev.cshlp.org
Melanoma is often considered one of the most aggressive and treatment-resistant human
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …
MITF in melanoma: mechanisms behind its expression and activity
ML Hartman, M Czyz - Cellular and Molecular Life Sciences, 2015 - Springer
MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …
Personalized oncology through integrative high-throughput sequencing: a pilot study
Individual cancers harbor a set of genetic aberrations that can be informative for identifying
rational therapies currently available or in clinical trials. We implemented a pilot study to …
rational therapies currently available or in clinical trials. We implemented a pilot study to …