Endocrine-disrupting chemicals (EDCs) are a broad class of molecules present in our
environment that are suspected to cause adverse effects in the endocrine system by …

The emergence and spread of drug resistance are the major challenges in malaria
eradication mission. Besides various strategies laid down by World Health Organization …

Quantitative systems pharmacology holds the promises of integrating results from laboratory
animals or in vitro human systems into the design of human pharmacokinetic …

Follicle-stimulating hormone (FSH) is produced in the pituitary and is essential for
reproduction. It specifically binds to a membrane receptor (FSHR) expressed in somatic cells …

Background Incorporation of omic data streams for building improved systems biology
models has great potential for improving their predictions of biological outcomes. We have …

Production of steroid hormones by the ovary plays a key role in the female phenotype
maintenance, as well as is critical for regular ovarian processes, including follicle growth …

The aim of this study was to establish a new QuEChERS (quick, easy, cheap, effective,
rugged and safe) method coupled to gas chromatography–mass spectrometry (GC–MS) …

This adverse outcome pathway details the linkage between inhibition of gonadal aromatase
activity in females and reproductive dysfunction, as measured through the adverse effect of …

The reproductive neuroendocrine axis, or hypothalamo-pituitary-gonadal (HPG) axis, is a
paragon of complex biological system involving numerous cell types, spread over several …

The increasing use of in vitro systems in pharmacology and toxicology has the potential to
yield high-throughput screening of molecules and in-depth mechanistic evaluations of …