Primary cilia are small, antenna-like organelles that detect and transduce chemical and
mechanical cues in the extracellular environment, regulating cell behavior and, in turn …

Abstract Background: Mineralocorticoid receptor antagonists (MRAs) protect cardiorenal
function by robust anti-inflammatory and antifibrotic functions beyond classical functions of …

Aldosterone is responsible for maintaining volume and potassium homeostasis. Although
high salt consumption should suppress aldosterone production, individuals with …

Various mammalian cells have autonomous cellular clocks that are produced by the
transcriptional cycle of clock genes. Cellular clocks provide circadian rhythms for cellular …

Cilia are essential for the ontogeny and function of many tissues, including the kidney. Here,
we report that transcription factor ERRγ ortholog estrogen related receptor gamma a (Esrrγa) …

Background and objective: The primary cilium is a small protrusion found on most
mammalian cells. It acts as a cellular antenna, being involved in various cell signaling …

The epithelial cells lining the lumen of the tubular system in the kidney are exposed to a
highly dynamic microenvironment, owing to the fluid flow of the pro-urine through this …

The adrenal gland is the major steroidogenic organ in mammals, and the Sonic hedgehog
(SHH) pathway is particularly important for its development and homeostatic maintenance …

Kidney disease is a prevalent issue across the United States, with one in seven adults
diagnosed with chronic kidney disease. As disease states progress, treatment options are …

the alternative cell surface route have remained enigmatic until recently, when breakthrough
work from the Alonso lab revealed a key role in the process for the midbody remnant …