Current success of immunotherapy in cancer has drawn attention to the subsets of TH cells
in the tumor which are critical for activation of anti-tumor response either directly by …

Cancer involves cells' abnormal growth and ability to invade or metastasize to different body
parts. Cancerous cells can divide uncontrollably and spread to other areas through the …

T helper (Th) cells have received extensive attention owing to their indispensable roles in
anti-tumor immune responses. Th1 and Th2 cells are two key subsets of Th cells that exist in …

The hepatitis B virus (HBV) X protein (HBX), a viral macromolecule, plays a vital role in the
development of HBV-related hepatocellular carcinoma (HCC). Increased expression of …

The in situ vaccine effect of radiation therapy (RT) has been shown to be limited in both
preclinical and clinical settings, possibly due to the inadequacy of RT alone to stimulate in …

Abstract Background Clinical trials using Cabozantinib have shown promising results in
metastatic breast cancer. This efficacy mainly results from removing and/or polarization of …

Although immune checkpoint-based cancer immunotherapy has shown significant efficacy
in various cancers, resistance still limits its therapeutic effects. Ubiquitination modification is …

HER2 is an established therapeutic target in breast, gastric, and gastroesophageal junction
carcinomas with HER2 overexpression or genomic alterations. The humanized monoclonal …

Hepatocellular carcinoma (HCC) has become the fourth leading cause of cancer-related
deaths worldwide; annually, approximately 830,000 deaths related to liver cancer are …

The prognostic value of SII (Systemic Immune-Inflammation Index) in HER-2-positive breast
cancer (BC) patients, regardless of whether they receive trastuzumab treatment, and its …