Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

Staphylococcus aureus can cause numerous different diseases, which has been attributed
to its large repertoire of virulence factors, many of which are under the control of the …

The agr locus encodes a quorum-sensing (QS) circuit required for the virulence of a
spectrum of Gram-positive pathogens and is, therefore, regarded as an important target for …

In Gram-positive bacteria such as Staphylococcus aureus and the coagulase-negative
staphylococci (CoNS), the accessory gene regulator (agr) is a highly conserved but …

In Staphylococcus aureus, virulence is under the control of a quorum sensing (QS) circuit
encoded in the accessory gene regulator (agr) genomic locus. Key to this pathogenic …

Bacteria can use chemical signals to assess their local population density in a process
called quorum sensing (QS). Many of these bacteria are common pathogens, including …

Staphylococci secrete autoinducing peptides (AIPs) as signalling molecules to regulate
population-wide behaviour. AIPs from non-Staphylococcus aureus staphylococci have …

The accessory gene regulator (agr) quorum-sensing system is arguably the most important
regulator of Staphylococcus virulence. The agr-system serves a crucial role in pathogenesis …

The bacterial pathogen Staphylococcus aureus controls many aspects of virulence by using
the accessory gene regulator (agr) quorum sensing (QS) system. The agr system is activated …

Staphylococcus epidermidis is frequently implicated in human infections associated with
indwelling medical devices due to its ubiquity in the skin flora and formation of robust …