Hyperpolarized water as universal sensitivity booster in biomolecular NMR

C Hilty, D Kurzbach, L Frydman - Nature protocols, 2022 - nature.com
NMR spectroscopy is the only method to access the structural dynamics of biomolecules at
high (atomistic) resolution in their native solution state. However, this method's low …

Studies of metabolism using 13C MRS of hyperpolarized probes

MM Chaumeil, C Najac, SM Ronen - Methods in enzymology, 2015 - Elsevier
First described in 2003, the dissolution dynamic nuclear polarization (DNP) technique,
combined with 13 C magnetic resonance spectroscopy (MRS), has since been used in …

Hyperpolarized 13C MR Spectroscopy Depicts in Vivo Effect of Exercise on Pyruvate Metabolism in Human Skeletal Muscle

JM Park, CE Harrison, J Ma, J Chen, J Ratnakar, Z Zun… - Radiology, 2021 - pubs.rsna.org
Background Pyruvate dehydrogenase (PDH) and lactate dehydrogenase are essential for
adenosine triphosphate production in skeletal muscle. At the onset of exercise, oxidation of …

The use of hyperpolarized carbon-13 magnetic resonance for molecular imaging

S Siddiqui, S Kadlecek, M Pourfathi, Y Xin… - Advanced drug delivery …, 2017 - Elsevier
Until recently, molecular imaging using magnetic resonance (MR) has been limited by the
modality's low sensitivity, especially with non-proton nuclei. The advent of hyperpolarized …

Placental physiology monitored by hyperpolarized dynamic 13C magnetic resonance

S Markovic, A Fages, T Roussel… - Proceedings of the …, 2018 - National Acad Sciences
Placental functions, including transport and metabolism, play essential roles in pregnancy.
This study assesses such processes in vivo, from a hyperpolarized MRI perspective …

Perspectives on paramagnetic NMR from a life sciences infrastructure

E Ravera, G Parigi, C Luchinat - Journal of Magnetic Resonance, 2017 - Elsevier
The effects arising in NMR spectroscopy because of the presence of unpaired electrons,
collectively referred to as “paramagnetic NMR” have attracted increasing attention over the …

Enhanced hyperpolarized chemical shift imaging based on a priori segmented information

G Farkash, S Markovic, M Novakovic… - Magnetic Resonance …, 2019 - Wiley Online Library
Purpose The purpose of the study was to develop an approach for improving the resolution
and sensitivity of hyperpolarized 13C MRSI based on a priori anatomical information derived …

Transcriptomic and metabolic analyses reveal salvage pathways in creatine-deficient AGAT−/− mice

M Stockebrand, AS Nejad, A Neu, KK Kharbanda… - Amino Acids, 2016 - Springer
Skeletal muscles require energy either at constant low (eg, standing and posture) or
immediate high rates (eg, exercise). To fulfill these requirements, myocytes utilize the …

Principles and Applications of Quantitative Parametric MRI in Tissue Engineering

M Kotecha - Magnetic Resonance Imaging in Tissue …, 2017 - Wiley Online Library
Magnetic resonance imaging (MRI) has contributed to the field of tissue engineering and
regenerative medicine (TERM) by providing a quantitative noninvasive assessment of tissue …

Reference-free unwarping of single-shot spatiotemporally encoded MRI using asymmetric self-refocused echoes acquisition

Y Chen, S Chen, J Zhong, Z Chen - Journal of Magnetic Resonance, 2015 - Elsevier
This paper presents a phase evolution rewinding algorithm for correcting the geometric and
intensity distortions in single-shot spatiotemporally encoded (SPEN) MRI with acquisition of …