Platelets are small anucleate cellular fragments that are released by megakaryocytes and
safeguard vascular integrity through a process termed 'haemostasis'. However, platelets …

Virchow's triad is traditionally invoked to explain pathophysiologic mechanisms leading to
thrombosis, alleging concerted roles for abnormalities in blood composition, vessel wall …

For a long time, blood coagulation and innate immunity have been viewed as interrelated
responses. Recently, the presence of leukocytes at the sites of vessel injury has been …

Endothelial cells (ECs) normally form an anticoagulant surface under physiological
conditions, but switch to support coagulation following pathogenic stimuli. This switch …

Thrombosis, or blood clot formation, and its sequelae remain a leading cause of morbidity
and mortality, and recurrent thrombosis is common despite current optimal therapy. Protein …

Deep vein thrombosis (DVT) with its major complication, pulmonary embolism, is a global
health problem. Mechanisms of DVT remain incompletely understood. Platelets play a role …

The contribution of NETs (neutrophil extracellular traps) to thrombus formation has been
intensively documented in both arterial and venous thrombosis in mice. We previously …

Venous thromboembolism constitutes one of the main causes of death during the
progression of a cancer. We previously demonstrated that tissue factor (TF)‐bearing cancer …

An inhibitor of tissue factor-induced coagulation was rediscovered in the 1980's and
subsequently named tissue factor pathway inhibitor (TFPI). Three isoforms of TFPI are …

A subset of patients with coronavirus 2 disease (COVID-19) experience neurological
complications. These complications include loss of sense of taste and smell, stroke, delirium …