[HTML][HTML] A treatise on Organophosphate pesticide pollution: Current strategies and advancements in their environmental degradation and elimination

J Kaushal, M Khatri, SK Arya - Ecotoxicology and Environmental Safety, 2021 - Elsevier
Pesticides have been used in the field of agriculture ever since their role in protection of
crops from pests which include four different categories namely insects, mites, rodents and …

Organophosphorus compounds and oximes: a critical review

F Worek, H Thiermann, T Wille - Archives of Toxicology, 2020 - Springer
Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population.
Treatment of OP poisoning is an ongoing challenge and burden for medical services …

[HTML][HTML] FDA-approved oximes and their significance in medicinal chemistry

J Dhuguru, E Zviagin, R Skouta - Pharmaceuticals, 2022 - mdpi.com
Despite the scientific advancements, organophosphate (OP) poisoning continues to be a
major threat to humans, accounting for nearly one million poisoning cases every year …

Organophosphorus poisoning: Acute respiratory distress syndrome (ARDS) and cardiac failure as cause of death in hospitalized patients

GP Ramadori - International Journal of Molecular Sciences, 2023 - mdpi.com
Industrial production of food for animals and humans needs increasing amounts of
pesticides, especially of organophosphates, which are now easily available worldwide …

The lesion site of organophosphorus-induced central apnea and the effects of antidotes

K Nomura, E Narimatsu, Y Oke, Y Oku - Scientific Reports, 2023 - nature.com
Organophosphorus poisoning kills individuals by causing central apnea; however, the
underlying cause of death remains unclear. Following findings that the pre-Bötzinger …

Acute organophosphate and carbamate pesticide poisonings–a five-year survey from the National Poison Control Center Of Serbia

ŽM Maksimović, J Jović-Stošić, S Vučinić… - Drug and chemical …, 2023 - Taylor & Francis
Pesticide poisonings, intentional as well as accidental, are common, especially in
undeveloped and developing countries. The goal of this study was to analyze the clinical …

Human CYP2C19 Substrate and Inhibitor Characterization of Organophosphate Pesticides

PA Vignaux, P Shriwas, A Revnew… - Chemical Research …, 2023 - ACS Publications
CYP2C19 is an important enzyme for organophosphate pesticide (OPP) metabolism.
Because the OPPs can be both substrates and inhibitors of CYP2C19, we screened 45 …

Post-modified polymer with imidazole groups as an efficient and reusable heterogeneous catalyst for organophosphate degradation

EC Leopoldino, G Pinheiro, RJ Alves, A Gerola… - Materials Today …, 2021 - Elsevier
In this work, the commercial polymer poly (ethylene-alt-maleic anhydride) was used as a
platform for the preparation of an imidazole-rich polymeric catalyst (PEIIm) designed for …

CON: Oximes should not be used routinely in organophosphorus insecticide poisoning

M Eddleston - British Journal of Clinical Pharmacology, 2022 - Wiley Online Library
Organophosphorus (OP) insecticide poisoning causes respiratory failure due to
acetylcholinesterase (AChE) inhibition. The AChE reactivating antidote pralidoxime was …

Drosophila melanogaster as a model organism for screening acetylcholinesterase reactivators

PE Macedo, JES Batista, LR Souza… - Journal of Toxicology …, 2024 - Taylor & Francis
The widely used insecticide chlorpyrifos (CP) is known to inhibit acetylcholinesterase
(AChE) activity attributed to result in various neurological disorders and acetylcholine …