Limbal stem cell deficiency: current treatment options and emerging therapies

M Haagdorens, SI Van Acker… - Stem cells …, 2016 - Wiley Online Library
Severe ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition
leading to decreased visual acuity, photophobia, and ocular pain. To restore the ocular …

[HTML][HTML] Amniotic membrane transplantation in the human eye

D Meller, M Pauklin, H Thomasen… - Deutsches Ärzteblatt …, 2011 - ncbi.nlm.nih.gov
Background Amniotic membrane transplantation (AMT) has a long tradition in ophthalmic
surgery and has become very popular recently because of newly developed methods of …

[HTML][HTML] Limbal stem-cell therapy and long-term corneal regeneration

P Rama, S Matuska, G Paganoni… - New England journal …, 2010 - Mass Medical Soc
Background Corneal renewal and repair are mediated by stem cells of the limbus, the
narrow zone between the cornea and the bulbar conjunctiva. Ocular burns may destroy the …

Simple limbal epithelial transplantation (SLET): a novel surgical technique for the treatment of unilateral limbal stem cell deficiency

VS Sangwan, S Basu, S MacNeil… - British Journal of …, 2012 - bjo.bmj.com
This study describes a novel surgical technique of limbal transplantation, which combines
the benefits of existing techniques while avoiding their difficulties. Six patients with unilateral …

[HTML][HTML] Simple limbal epithelial transplantation: long-term clinical outcomes in 125 cases of unilateral chronic ocular surface burns

S Basu, SP Sureka, SS Shanbhag, AR Kethiri, V Singh… - Ophthalmology, 2016 - Elsevier
Purpose This study describes the long-term clinical outcomes of autologous simple limbal
epithelial transplantation (SLET), a relatively new technique of limbal stem cell …

Navigating market authorization: the path holoclar took to become the first stem cell product approved in the European Union

G Pellegrini, D Ardigò, G Milazzo, G Iotti… - Stem Cells …, 2018 - academic.oup.com
Gene therapy, cell therapy, and tissue engineering have the potential to revolutionize the
treatment of disease and injury. Attaining marketing authorization for such advanced therapy …

The biocompatibility of porous silicon in tissues of the eye

SP Low, NH Voelcker, LT Canham, KA Williams - Biomaterials, 2009 - Elsevier
In this report, we explore the biocompatibility of thermally-oxidised, aminosilanised porous
silicon membranes and their potential to support human ocular cells in vitro and in vivo, in …

Clinical outcomes of xeno-free autologous cultivated limbal epithelial transplantation: a 10-year study

VS Sangwan, S Basu, GK Vemuganti… - British Journal of …, 2011 - bjo.bmj.com
Purpose Ocular burns can damage the corneal epithelial stem cells located at the limbus.
This study evaluated the efficacy of xeno-free autologous cell-based treatment of limbal stem …

13 years of cultured limbal epithelial cell therapy: a review of the outcomes

O Baylis, F Figueiredo, C Henein… - Journal of cellular …, 2011 - Wiley Online Library
The cornea is the clear tissue at the front of the eye which enables the transmission of light
to the retina for normal vision. The surface of the cornea is composed of an epithelium which …

[HTML][HTML] Cultured autologous oral mucosal epithelial cell sheet (CAOMECS) transplantation for the treatment of corneal limbal epithelial stem cell deficiency

C Burillon, L Huot, V Justin, S Nataf… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: Total bilateral corneal limbal epithelial stem cell deficiency (LSCD) cannot be
treated with the surgical transplantation of autologous limbus or cultured autologous limbal …