Epidural fibrosis causes serious complications in patients who have undergone
laminectomy. Pirfenidone is an effective antifibrotic agent but its effect on epidural fibrosis …

Epidural scarring occurs inevitably in the defect after spinal laminectomy, and thus how to
prevent or reduce it becomes a challenging topic. In the present study, an injectable …

Study Design: Experimental animal study. Objective: The authors conducted a study to
determine the efficacy and safety of the poly (d, l-lactic acid-co-glycolic acid)-poly (ethylene …

Post‐laminectomy/laminotomy epidural fibrosis (EF) has been implicated as an important
cause of failed back syndrome (FBS). The various clinical approaches used to control EF …

Lumbar laminectomy is commonly deemed as the most valid surgery for a series of lumbar
illnesses, such as lumbar disc herniation, which could lead to spinal canal stenosis …

Poloxamer-based thermo-sensitive sol-gel has been developed to reduce the incidence of
postoperative scar formation at the laminectomy site. The purpose of this study was to …

Aim To determine the role of MICAL2 in myofibroblasts differentiation and epidural fibrosis.
Background Epidural fibrosis (EF) may develop following laminectomy and aberrant …

Objectives: Epidural fibrosis, which develops during the post-operative period in 6–20% of
the patients who undergo lumbar spinal surgery, can cause persistent low-back pain and …

Background Post-vasectomy pain syndrome (PVPS) is difficult to treat. Direct damage to the
vas deferens, inflammation, compression of nerves through fibrotic adhesions, and …

The fibrosis that develops following laminectomy or discectomy often causes serious
complications, and the proliferation of fibroblasts is thought to be the major cause of epidural …