During the last decades, high-throughput assessment of gene expression in patient tissues
using microarray technology or RNA-Seq took center stage in clinical research. Insights into …

Transcriptome profiling techniques, such as microarrays and RNA sequencing (RNA-seq),
are valuable tools for deciphering the regulatory network underlying psoriasis and have …

Aberrant RNA splicing in keratinocytes drives inflammatory skin disorders. In the present
study, we found that the RNA helicase DDX5 was downregulated in keratinocytes from the …

Alteration of host cell splicing is a common feature of many viral infections which is
underappreciated because of the complexity and technical difficulty of studying alternative …

Rett syndrome (RTT) is a severe neurodevelopmental disorder that affects about 1 in 10,000
female live births. The underlying cause of RTT is mutations in the X-linked gene, methyl …

We developed a single-cell approach to detect CRISPR-modified mRNA transcript
structures. This method assesses how genetic variants at splicing sites and splicing factors …

Introduction: This study investigated serum miR-221-3p levels in psoriatic patients and the
characterization of serum miR-221-3p in keratinocyte inflammatory responses was further …

Despite significant interest in therapeutic targeting of splicing, few chemical probes are
available for the proteins involved in splicing. Here, we show that elaborated stereoisomeric …

Secukinumab and Dead Sea treatment result in clear skin for many psoriasis patients,
through distinct mechanisms. However, recurrence in the same areas after treatments …

Background Psoriasis is an immune-mediated disorder influenced by environmental factors
on a genetic basis. Despite advancements, challenges persist, including the diminishing …